PMID- 34209032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210723
IS  - 2414-6366 (Electronic)
IS  - 2414-6366 (Linking)
VI  - 6
IP  - 3
DP  - 2021 Jun 30
TI  - Encephalitis in Thailand: A Neglected Disease Increasingly Caused by Enterovirus.
LID - 10.3390/tropicalmed6030117 [doi]
LID - 117
AB  - From 2013 to 2018, the Thai Red Cross Emerging Infectious Disease-Health Science 
      Center (TRC-EID-HS), in collaboration with the Department of Disease Control 
      (DDC) and the Ministry of Public Health (MOPH) Thailand, conducted encephalitis 
      surveillance. A total of 1700 cerebrospinal fluid (CSF) samples from patients 
      with encephalitis were tested by a predesigned multiplex PCR. Diagnosis was made 
      in 318 cases (18.7%), 86 (27%) of which were caused by Epstein-Barr virus (EBV), 
      55 (17.3%) by enteroviruses (EV), 36 (11.3%) by varicella-zoster virus (VZV), 31 
      (9.7%) by cytomegalovirus (CMV), 25 (7.8%) by herpes simplex virus type 1 
      (HSV-1), and 20 (6.3%) by human herpesvirus 6 (HHV-6). Results were compared with 
      3099 CSF samples from patients with encephalitis collected between 2002 to 2012, 
      which were tested by specific PCR assays. Diagnosis was made in 337 (10.9%) of 
      these cases, and 91 (27%) were CMV, 79 (23.4%) were VZV, 72 (21.4%) were EBV, 39 
      (11.6%) were EVs, 39 (11.6%) were HSV-1, 33 (9.8%) were HSV-2, and 2 (0.6%) were 
      Dengue virus (DENV). The change in the pattern toward EVs as a major cause of 
      viral encephalitis was unexpected, and a change in viral neurotropism may be 
      responsible.
FAU - Hemachudha, Pasin
AU  - Hemachudha P
AUID- ORCID: 0000-0001-9241-3475
AD  - Thai Red Cross Emerging Infectious Diseases Health Science Centre, World Health 
      Organization Collaborating Centre for Research and Training on Viral Zoonoses, 
      King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn 
      University, Bangkok 10330, Thailand.
FAU - Petcharat, Sininat
AU  - Petcharat S
AUID- ORCID: 0000-0001-8381-5608
AD  - Thai Red Cross Emerging Infectious Diseases Health Science Centre, World Health 
      Organization Collaborating Centre for Research and Training on Viral Zoonoses, 
      King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn 
      University, Bangkok 10330, Thailand.
FAU - Hinjoy, Soawapak
AU  - Hinjoy S
AUID- ORCID: 0000-0001-6127-2665
AD  - Office of International Cooperation, Department of Disease Control, Ministry of 
      Public Health, Nonthaburi 11000, Thailand.
FAU - Saraya, Abhinbhen W
AU  - Saraya AW
AD  - Thai Red Cross Emerging Infectious Diseases Health Science Centre, World Health 
      Organization Collaborating Centre for Research and Training on Viral Zoonoses, 
      King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn 
      University, Bangkok 10330, Thailand.
FAU - Hemachudha, Thiravat
AU  - Hemachudha T
AUID- ORCID: 0000-0001-9480-2247
AD  - Thai Red Cross Emerging Infectious Diseases Health Science Centre, World Health 
      Organization Collaborating Centre for Research and Training on Viral Zoonoses, 
      King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn 
      University, Bangkok 10330, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20210630
PL  - Switzerland
TA  - Trop Med Infect Dis
JT  - Tropical medicine and infectious disease
JID - 101709042
PMC - PMC8293361
OTO - NOTNLM
OT  - Thailand
OT  - encephalitis
OT  - enterovirus
OT  - neurological infection
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/06/30
CRDT- 2021/07/02 01:37
PHST- 2021/05/15 00:00 [received]
PHST- 2021/06/25 00:00 [revised]
PHST- 2021/06/28 00:00 [accepted]
PHST- 2021/07/02 01:37 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/06/30 00:00 [pmc-release]
AID - tropicalmed6030117 [pii]
AID - tropicalmed-06-00117 [pii]
AID - 10.3390/tropicalmed6030117 [doi]
PST - epublish
SO  - Trop Med Infect Dis. 2021 Jun 30;6(3):117. doi: 10.3390/tropicalmed6030117.