PMID- 34209495
OWN - NLM
STAT- MEDLINE
DCOM- 20210714
LR  - 20210714
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 13
DP  - 2021 Jun 29
TI  - Role of Calixarene in Chemotherapy Delivery Strategies.
LID - 10.3390/molecules26133963 [doi]
LID - 3963
AB  - Since cancer is a multifactorial disease with a high mortality rate, the study of 
      new therapeutic strategies is one of the main objectives in modern research. 
      Numerous chemotherapeutic agents, although widely used, have the disadvantage of 
      being not very soluble in water or selective towards cancerous cells, with 
      consequent side effects. Therefore, in recent years, a greater interest has 
      emerged in innovative drug delivery systems (DDSs) such as calixarene, a 
      third-generation supramolecular compound. Calixarene and its water-soluble 
      derivatives show good biocompatibility and have low cytotoxicity. Thanks to their 
      chemical-physical characteristics, calixarenes can be easily functionalized, and 
      by itself can encapsulate host molecules forming nanostructures capable of 
      releasing drugs in a controlled way. The encapsulation of anticancer drugs in a 
      calixarene derivate improves their bioavailability and efficacy. Thus, the use of 
      calixarenes as carriers of anticancer drugs could reduce their side effects and 
      increase their affinity towards the target. This review summarizes the numerous 
      research advances regarding the development of calixarene nanoparticles capable 
      of encapsulating various anticancer drugs.
FAU - Basilotta, Rossella
AU  - Basilotta R
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Mannino, Deborah
AU  - Mannino D
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Filippone, Alessia
AU  - Filippone A
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Casili, Giovanna
AU  - Casili G
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Prestifilippo, Angela
AU  - Prestifilippo A
AD  - Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy.
FAU - Colarossi, Lorenzo
AU  - Colarossi L
AUID- ORCID: 0000-0001-9988-2362
AD  - Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy.
FAU - Raciti, Gabriele
AU  - Raciti G
AD  - IOM Ricerca Srl, Via Penninazzo 11, 95029 Viagrande, Italy.
FAU - Esposito, Emanuela
AU  - Esposito E
AUID- ORCID: 0000-0002-2663-6387
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Campolo, Michela
AU  - Campolo M
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210629
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 130036-26-9 (Calixarenes)
SB  - IM
MH  - *Antineoplastic Agents/chemistry/therapeutic use
MH  - *Calixarenes/chemistry/therapeutic use
MH  - *Drug Carriers/chemistry/therapeutic use
MH  - Humans
MH  - *Nanoparticles/chemistry/therapeutic use
PMC - PMC8272165
OTO - NOTNLM
OT  - calixarene
OT  - cancer
OT  - chemotherapeutic agents
OT  - drug delivery system (DDS)
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/15 06:00
PMCR- 2021/06/29
CRDT- 2021/07/02 01:38
PHST- 2021/06/04 00:00 [received]
PHST- 2021/06/23 00:00 [revised]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/07/02 01:38 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/15 06:00 [medline]
PHST- 2021/06/29 00:00 [pmc-release]
AID - molecules26133963 [pii]
AID - molecules-26-03963 [pii]
AID - 10.3390/molecules26133963 [doi]
PST - epublish
SO  - Molecules. 2021 Jun 29;26(13):3963. doi: 10.3390/molecules26133963.