PMID- 34209501 OWN - NLM STAT- MEDLINE DCOM- 20210705 LR - 20210727 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 57 IP - 7 DP - 2021 Jun 29 TI - Effect of Intermittent Hypoxia on Metabolic Syndrome and Insulin Resistance in the General Male Population. LID - 10.3390/medicina57070668 [doi] LID - 668 AB - Background and objectives: Obstructive sleep apnea (OSA) is closely associated with insulin resistance (IR) and is an independent risk factor for incident type 2 diabetes mellitus (T2DM). Most studies evaluate the correlation between OSA and IR in only obese or T2DM patients. Therefore, we tried to investigate the effect of OSA on metabolic syndrome and IR in the general healthy male population. Materials and Methods: 184 subjects who visited a preventive health examination program were recruited for this study. All subjects received overnight polysomnography by a portable device (Watch-PAT 200). We examined several metabolic parameters and a homeostasis model of assessment for insulin resistance index (HOMA-IR). The subjects were divided into three groups by AHI (Apnea-hyponea index): normal group (AHI < 5), mild OSA group (5 /= 15). They were also divided into two groups according to minimum oxygen saturation: low group, Min-SpO2 < 88%; and high group, Min-SpO2 >/= 88%. Results: Parameters of metabolic syndrome, including waist circumference, systolic and diastolic blood pressure, triglyceride, and high-density lipoprotein cholesterol showed significant differences among the AHI groups. Furthermore, HOMA-IR showed significant differences among the AHI groups. Those parameters, including metabolic syndrome and HOMA-IR, also showed differences between Min-SpO2 groups. Conclusions: In summary, this study helps confirm that AHI is associated with HOMA-IR in the general male population. Furthermore, the severity of AHI correlated with the parameters of metabolic syndrome. Therefore, AHI might be an indicator for evaluating both T2DM and metabolic syndrome, even in the general male population. FAU - Lee, Jung-Yup AU - Lee JY AUID- ORCID: 0000-0002-0823-4245 AD - Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. FAU - Kim, Chan-Won AU - Kim CW AUID- ORCID: 0000-0001-5836-1974 AD - Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. FAU - Lee, Kyung-Chul AU - Lee KC AD - Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. FAU - Lee, Jae-Hyuk AU - Lee JH AD - Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. FAU - Kang, Sung-Hun AU - Kang SH AD - Department of Biomedical Sciences, College of Medicine, Hallym University, Chuncheon 24252, Korea. FAU - Li, Sung-Won AU - Li SW AD - Department of Otorhinolaryngology-Head and Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Gyeonggi-do, Korea. FAU - Kim, Kyubo AU - Kim K AD - Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Gyeonggi-do, Korea. FAU - Hong, Seok-Jin AU - Hong SJ AUID- ORCID: 0000-0002-9061-0552 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Gyeonggi-do, Korea. LA - eng GR - NRF-2018R1C1B6008596/National Research Foundation of Korea/ PT - Journal Article DEP - 20210629 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Humans MH - Hypoxia/epidemiology MH - *Insulin Resistance MH - Male MH - *Metabolic Syndrome/complications/epidemiology PMC - PMC8303242 OTO - NOTNLM OT - hypoxia OT - insulin resistance OT - metabolic syndrome OT - obstructive sleep apnea COIS- The authors declare no conflict of interest. EDAT- 2021/07/03 06:00 MHDA- 2021/07/06 06:00 PMCR- 2021/06/29 CRDT- 2021/07/02 01:38 PHST- 2021/05/10 00:00 [received] PHST- 2021/06/24 00:00 [revised] PHST- 2021/06/25 00:00 [accepted] PHST- 2021/07/02 01:38 [entrez] PHST- 2021/07/03 06:00 [pubmed] PHST- 2021/07/06 06:00 [medline] PHST- 2021/06/29 00:00 [pmc-release] AID - medicina57070668 [pii] AID - medicina-57-00668 [pii] AID - 10.3390/medicina57070668 [doi] PST - epublish SO - Medicina (Kaunas). 2021 Jun 29;57(7):668. doi: 10.3390/medicina57070668.