PMID- 34210318
OWN - NLM
STAT- MEDLINE
DCOM- 20220125
LR  - 20240402
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jul 1
TI  - Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary 
      patterns on cardio-metabolic risk factors among obese and overweight women.
PG  - 138
LID - 10.1186/s12902-021-00800-y [doi]
LID - 138
AB  - BACKGROUND: Caveolin-1 (CAV-1) is a cholesterol-dependent essential component 
      located in caveolae. Several studies have been CAV-1 related to cardio-metabolic 
      parameters in animal models, however, there are few studies in humans. 
      Importantly, there is no study has investigated the interaction between CAV-1 
      rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors. 
      METHODS: The current cross-sectional study was conducted on 404 overweight and 
      obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 
      genotype was measured by the PCR-RFLP method. The anthropometric measurements, 
      serum lipid profile, and inflammatory markers were measured by standard 
      protocols. RESULTS: There was a significant interaction between CAV-1 rs3807992 
      and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL 
      (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) 
      (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was 
      related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the 
      significant interactions were observed between CAV-1 rs3807992 and unhealthy DP 
      in relation to triglyceride (TG) (P-interaction = 0.001), aspartate 
      aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant 
      protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following 
      the unhealthy DP had lower levels of TG, AST and MCP-1. CONCLUSIONS: Our study 
      revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in 
      relation to cardio-metabolic risk factors; A-allele carriers might be more 
      sensitive to dietary composition compared to GG homozygotes. Following a healthy 
      DP in A-allele-carriers may be improved their genetic association with 
      cardio-metabolic risk factors.
FAU - Abaj, Faezeh
AU  - Abaj F
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and 
      Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences (IUMS), Isfahan, Iran.
FAU - Alvandi, Ehsan
AU  - Alvandi E
AD  - School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
FAU - Yekaninejad, Mir Saeed
AU  - Yekaninejad MS
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Mirzaei, Khadijeh
AU  - Mirzaei K
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran. 
      mirzaei_kh@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (CAV1 protein, human)
RN  - 0 (Caveolin 1)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - *Cardiometabolic Risk Factors
MH  - Caveolin 1/*genetics
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Diet/*adverse effects
MH  - Diet Surveys
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - Overweight/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Triglycerides/blood
PMC - PMC8247154
OTO - NOTNLM
OT  - Cardio-metabolic
OT  - Caveolin-1
OT  - Diet
OT  - Gene-environment interaction
OT  - Personalized diet
OT  - Polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/07/01
CRDT- 2021/07/02 05:37
PHST- 2020/11/01 00:00 [received]
PHST- 2021/06/19 00:00 [accepted]
PHST- 2021/07/02 05:37 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 10.1186/s12902-021-00800-y [pii]
AID - 800 [pii]
AID - 10.1186/s12902-021-00800-y [doi]
PST - epublish
SO  - BMC Endocr Disord. 2021 Jul 1;21(1):138. doi: 10.1186/s12902-021-00800-y.