PMID- 34211021
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jul 1
TI  - Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural 
      infection but not after vaccination.
PG  - 13664
LID - 10.1038/s41598-021-92926-1 [doi]
LID - 13664
AB  - Mumps is nowadays re-emerging despite vaccination. The contribution of T cell 
      immunity to protection against mumps has not been clearly defined. Previously, we 
      described a set of 41 peptides that were eluted from human leukocyte antigen 
      (HLA) class I molecules of mumps virus (MuV)-infected cells. Here, we confirmed 
      immunogenicity of five novel HLA-B*07:02- and HLA-A*01:01-restricted MuV T cell 
      epitopes from this set of peptides. High frequencies of T cells against these 
      five MuV epitopes could be detected ex vivo in all tested mumps patients. 
      Moreover, these epitope-specific T cells derived from mumps patients displayed 
      strong cytotoxic activity. In contrast, only marginal T cell responses against 
      these novel MuV epitopes could be detected in recently vaccinated persons, 
      corroborating earlier findings. Identifying which MuV epitopes are dominantly 
      targeted in the mumps-specific CD8(+) T- response is an important step towards 
      better understanding in the discrepancies between natural infection or 
      vaccination-induced cell-mediated immune protection.
FAU - Kaaijk, Patricia
AU  - Kaaijk P
AD  - Centre for Infectious Disease Control, National Institute for Public Health and 
      the Environment (RIVM), PO box 41, 3720, BA, Bilthoven, The Netherlands. 
      patricia.kaaijk@rivm.nl.
FAU - Emmelot, Maarten E
AU  - Emmelot ME
AD  - Centre for Infectious Disease Control, National Institute for Public Health and 
      the Environment (RIVM), PO box 41, 3720, BA, Bilthoven, The Netherlands.
FAU - Meiring, Hugo D
AU  - Meiring HD
AD  - Intravacc (Institute for Translational Vaccinology), Bilthoven, The Netherlands.
FAU - van Els, Cecile A C M
AU  - van Els CACM
AD  - Centre for Infectious Disease Control, National Institute for Public Health and 
      the Environment (RIVM), PO box 41, 3720, BA, Bilthoven, The Netherlands.
FAU - de Wit, Jelle
AU  - de Wit J
AD  - Centre for Infectious Disease Control, National Institute for Public Health and 
      the Environment (RIVM), PO box 41, 3720, BA, Bilthoven, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210701
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - Humans
MH  - Mumps/*immunology/prevention & control
MH  - Mumps virus/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Vaccination
MH  - Young Adult
PMC - PMC8249633
COIS- The authors declare no competing interests.
EDAT- 2021/07/03 06:00
MHDA- 2021/11/09 06:00
PMCR- 2021/07/01
CRDT- 2021/07/02 06:10
PHST- 2021/01/14 00:00 [received]
PHST- 2021/06/18 00:00 [accepted]
PHST- 2021/07/02 06:10 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 10.1038/s41598-021-92926-1 [pii]
AID - 92926 [pii]
AID - 10.1038/s41598-021-92926-1 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jul 1;11(1):13664. doi: 10.1038/s41598-021-92926-1.