PMID- 34212547
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 13
IP  - 4
DP  - 2021 Jul
TI  - Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK 
      Asthmatics.
PG  - 609-622
LID - 10.4168/aair.2021.13.4.609 [doi]
AB  - PURPOSE: Although genome-wide association studies (GWASs) represent the most 
      powerful approach for identifying genes that influence asthma, to date, no 
      studies have established genetic susceptibility to asthma in the Korean 
      population. This study aimed to identify genetic variants associated with adult 
      Korean asthmatics and compare them with the significant single nucleotide 
      polymorphisms (SNPs) of UK asthmatics from the UK Biobank. METHODS: Patients were 
      defined as having asthma if they were diagnosed by a doctor or taking medications 
      for asthma. Controls were defined as individuals without asthma or chronic 
      obstructive pulmonary disease. We performed quality control, genotype imputation, 
      GWAS, and PrediXcan analyses. In the GWAS, a P value of < 5 x 10(-8) was 
      considered significant. We compared significant SNPs between Korean and UK 
      patients with asthma. RESULTS: A total of 1,386 asthmatic patients and 5,205 
      controls were analyzed. The SNP rs1770, located near the human leukocyte antigen 
      (HLA)-DQB1, was the most significant SNP (P = 4.5 x 10(-10)). In comparison with 
      24 SNPs in a GWAS of UK asthmatics, six SNPs were significant with the same odds 
      ratio (OR) direction, including signals related to type 2 inflammation (e.g., 
      IL1RL1, TSLP, and GATA3) and mucus plugging (e.g., MUC5AC). HLA-DQA1 showed an 
      opposite OR direction. The HLA-DQB1 gene demonstrated significantly imputed mRNA 
      expression in the lung tissue and whole blood. CONCLUSIONS: The SNP rs1770 of 
      HLA-DQB1 was the most significant in Korean asthmatics. Similarities and 
      discrepancies were found in the genetic variants between Korean and UK 
      asthmatics. GWAS of Korean asthmatics should be replicated and compared with 
      those of GWAS of other ethnicities.
CI  - Copyright (c) 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - An, Jin
AU  - An J
AUID- ORCID: 0000-0001-5416-2660
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
AD  - Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University 
      Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
FAU - Do, Ah Ra
AU  - Do AR
AUID- ORCID: 0000-0002-4259-8309
AD  - Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, 
      Korea.
FAU - Kang, Hae Yeon
AU  - Kang HY
AUID- ORCID: 0000-0003-3965-7539
AD  - Department of Internal Medicine, Healthcare Research Institute, Seoul National 
      University Hospital Healthcare System Gangnam Center, Seoul, Korea.
FAU - Kim, Woo Jin
AU  - Kim WJ
AUID- ORCID: 0000-0003-2927-370X
AD  - Department of Internal Medicine and Environmental Health Center, School of 
      Medicine, Kangwon National University, Chuncheon, Korea.
FAU - Lee, Sanghun
AU  - Lee S
AUID- ORCID: 0000-0002-0573-9555
AD  - Department of Medical Consilience, Graduate School, Dankook university, Yongin, 
      Korea.
FAU - Lee, Ji Hyang
AU  - Lee JH
AUID- ORCID: 0000-0003-4286-3114
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
FAU - Song, Woo Jung
AU  - Song WJ
AUID- ORCID: 0000-0002-4630-9922
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
FAU - Kwon, Hyouk Soo
AU  - Kwon HS
AUID- ORCID: 0000-0001-7695-997X
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
FAU - Cho, You Sook
AU  - Cho YS
AUID- ORCID: 0000-0001-8767-2667
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
FAU - Moon, Hee Bom
AU  - Moon HB
AUID- ORCID: 0000-0001-7542-5917
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea.
FAU - Hu, Sile
AU  - Hu S
AUID- ORCID: 0000-0002-8437-7387
AD  - Experimental Studies, Airways Disease Section, National Heart & Lung Institute, 
      Imperial College London, London, United Kingdom.
FAU - Adcock, Ian M
AU  - Adcock IM
AUID- ORCID: 0000-0003-2101-8843
AD  - Experimental Studies, Airways Disease Section, National Heart & Lung Institute, 
      Imperial College London, London, United Kingdom.
FAU - Chung, Kian Fan
AU  - Chung KF
AUID- ORCID: 0000-0001-7101-1426
AD  - Experimental Studies, Airways Disease Section, National Heart & Lung Institute, 
      Imperial College London, London, United Kingdom.
FAU - Won, Sungho
AU  - Won S
AUID- ORCID: 0000-0001-5751-5089
AD  - Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, 
      Korea.
AD  - Department of Public Health Sciences, School of Public Health, Seoul National 
      University, Seoul, Korea.
AD  - Institute of Health and Environment, Seoul National University, Seoul, Korea. 
      sunghow@gmail.com.
FAU - Kim, Tae Bum
AU  - Kim TB
AUID- ORCID: 0000-0001-5663-0640
AD  - Department of Allergy and Clinical Immunology, Asan Medical Center, University of 
      Ulsan College of Medicine, Seoul, Korea. tbkim@amc.seoul.kr.
LA  - eng
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
GR  - MR/T010371/1/MRC_/Medical Research Council/United Kingdom
GR  - 2019M3E5D3073365/NRF/National Research Foundation of Korea/Korea
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC8255356
OTO - NOTNLM
OT  - Genome-wide association study
OT  - Korea
OT  - United Kingdom
OT  - asthma
OT  - genetics
OT  - human leukocyte antigen
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/07/01
CRDT- 2021/07/02 07:08
PHST- 2020/12/07 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/05/12 00:00 [accepted]
PHST- 2021/07/02 07:08 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 13.609 [pii]
AID - 10.4168/aair.2021.13.4.609 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2021 Jul;13(4):609-622. doi: 
      10.4168/aair.2021.13.4.609.