PMID- 34212905
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210824
IS  - 2531-6745 (Electronic)
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 92
IP  - 3
DP  - 2021 Jul 1
TI  - Understanding the association between endothelial dysfunction and left ventricle 
      diastolic dysfunction in development of coronary artery disease and heart 
      failure.
PG  - e2021204
LID - 10.23750/abm.v92i3.11495 [doi]
LID - e2021204
AB  - Cardiovascular diseases (CVDs)  have been the most common cause of death 
      worldwide for decades. Until recently the most affected patients were middle-aged 
      and elderly, predominantly men, with more frequent ST elevation myocardial 
      infarction  (STEMI) caused by obstructive coronary artery disease (CAD). However, 
      in the last two decades we have noticed an increased incidence of ischemia with 
      non-obstructive coronary arteries (INOCA), which includes myocardial infarction 
      with non-obstructive coronary arteries (MINOCA) and non-myocardial infarction 
      syndromes, such as microvascular and vasospastic angina, conditions that have 
      been particularly pronounced in women and young adults - the population we 
      considered low-risky till than. Therefore, it has become apparent that for this 
      group of patients conventional methods of assessing the risk of future 
      cardiovascular (CV) events are no longer specific and sensitive enough. Heart 
      failure with preserved ejection fraction (HFpEF) is another disease, the 
      incidence of which has been rising rapidly during last two decades, and 
      predominantly affects elderly population. Although the etiology and 
      pathophysiology of INOCA and HFpEF are complex and not fully understood, there is 
      no doubt that the underlying cause of both conditions is endothelial dysfunction 
      (ED) which further promotes the development of left ventricular diastolic 
      dysfunction (LVDD). Plasma biomarkers of ED, as well as natriuretic peptides 
      (NPs), have been intensively investigated recently, and some of them have great 
      potential for early detection and better assessment of CV risk in the future.
FAU - Susic, Livija
AU  - Susic L
AD  - Department of Internal Medicine, Osijek-Baranja County Health Center, Osijek, 
      Croatia and Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, 
      Osijek, Croatia. livija.susic@gmail.com.
FAU - Maricic, Lana
AU  - Maricic L
AD  - Cardiology, University Hospital Centre Osijek, Osijek, Croatia; Josip Juraj 
      Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia. 
      dr.lmaricic@gmail.com.
FAU - Vincelj, Josip
AU  - Vincelj J
AD  - Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, 
      Croatia. josip.vinceljgg@gmail.com.
FAU - Vadoci, Milena
AU  - Vadoci M
AD  - 1Department of Internal Medicine, Osijek-Baranja County Health Center, Osijek, 
      Croatia. milenavadoci23@gmail.com.
FAU - Susic, Tihomir
AU  - Susic T
AD  - The Information Institute Osijek, Osijek, Croatia. tihomir.susic@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
SB  - IM
MH  - Aged
MH  - *Coronary Artery Disease/etiology
MH  - Female
MH  - *Heart Failure/epidemiology/etiology
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Left/etiology
PMC - PMC8343725
COIS- Each author declares that he or she has no commercial associations (e.g. 
      consultancies, stock ownership, equity interest, patent/licensing arrangement 
      etc.) that might pose a conflict of interest in connection with the submitted 
      article.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/13 06:00
PMCR- 2021/01/01
CRDT- 2021/07/02 09:03
PHST- 2021/03/23 00:00 [received]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/07/02 09:03 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - ACTA-93-204 [pii]
AID - 10.23750/abm.v92i3.11495 [doi]
PST - epublish
SO  - Acta Biomed. 2021 Jul 1;92(3):e2021204. doi: 10.23750/abm.v92i3.11495.