PMID- 34213135
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210702
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 37
IP  - 12
DP  - 2019 Dec 8
TI  - [Determination of sodium picosulfate in enzyme products by high-performance 
      liquid chromatography-tandem mass spectrometry].
PG  - 1331-1336
LID - 10.3724/SP.J.1123.2019.05035 [doi]
AB  - A method based on high-performance liquid chromatography-tandem mass spectrometry 
      was developed for the determination of sodium picosulfate in enzyme products. 
      Sodium picosulfate is a new slimming aid that is illegally added to food 
      products. The existing analytical methods are not suitable for application to 
      jellies and gel candies, thus triggering the need for developing a new method. 
      The samples were extracted with water and passed through a polyamide cartridge. 
      The extracts were separated on a Thermo Accucore RP-MS column (100 mmx2.1 mm, 2.6 
      mum) using acetonitrile-10 mmol/L ammonium acetate solution (15:85, v/v) as the 
      mobile phase. The flow rate of the mobile phase was 0.3 mL/min, and the column 
      temperature was 35 ℃. Detection was carried out in the multiple reaction 
      monitoring (MRM) mode. Quantification analysis was performed by the external 
      standard method. The results showed that sodium picosulfate had a good linear 
      relationship in the range of 5-500 mug/L, and the correlation coefficient (r) was 
      0.9999. The limit of detection (LOD) was 0.05 mg/kg. The average recoveries of 
      sodium picosulfate in different matrices were in the range of 89.2%-111.8%, with 
      the relative standard deviations (RSDs) of 2.5%-10.4%. The method was applied to 
      the analysis of 152 samples, and 58 positive samples were detected. The positive 
      rate was 38.2%. The developed method is accurate and sensitive, and it is 
      suitable for detecting sodium picosulfate in enzyme products.
FAU - He, Jiawen
AU  - He J
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
FAU - Wen, Jiaxin
AU  - Wen J
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
FAU - Lai, Yuhong
AU  - Lai Y
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
FAU - Liu, Yaxiong
AU  - Liu Y
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
FAU - Cao, Yajing
AU  - Cao Y
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
FAU - Chen, Qiao
AU  - Chen Q
AD  - Guangdong Institute for Drug Control, Guangzhou 510180, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
SB  - IM
OTO - NOTNLM
OT  - enzyme product
OT  - high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
OT  - illegally added
OT  - slimming
OT  - sodium picosulfate
EDAT- 2019/12/08 00:00
MHDA- 2019/12/08 00:01
CRDT- 2021/07/02 09:12
PHST- 2021/07/02 09:12 [entrez]
PHST- 2019/12/08 00:00 [pubmed]
PHST- 2019/12/08 00:01 [medline]
AID - 10.3724/SP.J.1123.2019.05035 [doi]
PST - ppublish
SO  - Se Pu. 2019 Dec 8;37(12):1331-1336. doi: 10.3724/SP.J.1123.2019.05035.