PMID- 34213188
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 38
IP  - 8
DP  - 2020 Aug 8
TI  - [Determination of 18 phenolic compounds in water by gas chromatography-tandem 
      mass spectrometry coupled with solid phase extraction].
PG  - 953-960
LID - 10.3724/SP.J.1123.2020.01016 [doi]
AB  - At present, the kinds and the hazards of phenolic compounds in water were 
      unclear. Research aimed at methods for the simultaneous detection of multiple 
      phenolic compounds is still in its nascent stages. It is necessary to establish a 
      method for the simultaneous determination of phenolic compounds in water. An 
      analytical method was developed for the simultaneous determination of the 18 
      phenolic compounds in water by gas chromatography-tandem mass spectrometry 
      (GC-MS/MS) coupled with solid phase extraction (SPE). The phenolic compounds in 
      water were enriched and separated on an SPE column. The optimal pretreatment 
      method was established by optimizing the chromatographic and mass spectrometric 
      conditions. The effects of the initial pH of the water sample, type of eluting 
      solvent, and dosage of the washing solution were investigated. Then, the 18 
      phenolic compounds in the water samples were determined. The optimal pretreatment 
      extraction conditions were determined to be as follows:final pH of water sample, 
      3.0; eluting solvent, ethyl acetate (10 mL); and elution rate, 1 mL/min. The 
      phenolic compounds enriched and purified by SPE were finally determined by 
      GC-MS/MS with an electrospray ionization (EI) source. The phenolic compounds were 
      then quantitatively analyzed by the external standard method. The average 
      recoveries of the 18 phenolic compounds were in the range of 51.7%-117.3% at four 
      spiked levels, and the relative standard deviations (RSDs) were in the range of 
      3.1%-7.4%. The limits of detections (LODs) were 0.04-0.6 mug/L. Good linear 
      relationships were observed for the phenolic compounds in their corresponding 
      concentration ranges. The developed method was applied to determine the phenolic 
      compounds in six kinds of water samples from rivers and lakes, domestic water, 
      and process water. Fifteen of the phenolic compounds were detected, but 
      4-nonylphenol, 3-methyl-4-nitrophenol, and 2-methyl-4,6-dinitrophenol were not. 
      Moreover, bisphenol A, 2,4,6-tribromophenol, and 2,4-dibromophnol had the highest 
      contents of 49.4 mug/L. The contents and kinds of phenolic compounds in the rivers 
      and lakes were highest. However, the contents of phenolic compounds in the 
      domestic water were adverse compared with the rivers and lakes, in accord with 
      National Standard GB 8537-2008. As opposed to traditional analytical methods, the 
      present method is characterized by simple operation without derivative or the 
      need for anhydrous sodium sulfate for water removal, as well as high sensitivity, 
      good stability, and reliability. The establishment of this method has important 
      theoretical and practical significance for the development of standards and for 
      the control of residue phenolic residue levels in water.
FAU - Li, Yang
AU  - Li Y
AD  - College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315211, 
      China.
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Zhang, Shufen
AU  - Zhang S
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Xing, Jiali
AU  - Xing J
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Ying, Lu
AU  - Ying L
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Cheng, Hai
AU  - Cheng H
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Zheng, Ruihang
AU  - Zheng R
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Mao, Lingyan
AU  - Mao L
AD  - Ningbo Institute for Food Control, Ningbo 315048, China.
FAU - Li, Hesheng
AU  - Li H
AD  - College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315211, 
      China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
SB  - IM
OTO - NOTNLM
OT  - determination
OT  - gas chromatography tandem mass spectrometry (GC-MS/MS)
OT  - phenolic compounds
OT  - solid phase extraction (SPE)
OT  - water
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
CRDT- 2021/07/02 09:12
PHST- 2021/07/02 09:12 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
AID - 10.3724/SP.J.1123.2020.01016 [doi]
PST - ppublish
SO  - Se Pu. 2020 Aug 8;38(8):953-960. doi: 10.3724/SP.J.1123.2020.01016.