PMID- 34213284
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 38
IP  - 7
DP  - 2020 Jul 8
TI  - [Rapid determination of trace ciprofloxacin residue in milk samples using 
      molecularly imprinted membrane extraction-high performance liquid 
      chromatography-tandem mass spectrometry].
PG  - 775-781
LID - 10.3724/SP.J.1123.2020.02017 [doi]
AB  - An enrofloxacin (ENR) molecularly imprinted membrane (MIM) was prepared with a 
      polyvinylidenedifluoride (PVDF) membrane as the carrier, ENR as the dummy 
      template molecule, alpha-methacrylic acid (MAA) as the functional monomer, ethylene 
      glycol dimethacrylate (EGDMA) as the cross-linker, and a chloroform-methanol 
      mixture solvent as the porogen. The MIM showed excellent selectivity, high 
      adsorption capacity, and high adsorption rate for ciprofloxacin. Additionally, a 
      method combining molecularly imprinted membrane extraction (MIME) and high 
      performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was 
      developed and validated for the selective analysis of trace ciprofloxacin residue 
      in milk samples. The sample pretreatment involved only a single step of protein 
      precipitation. Ciprofloxacin showed good linearity in mass concentration range of 
      0.1-200 mug/L with a high correlation coefficient (r(2)>0.9996). The limit of 
      detection (LOD, S/N=3) and limit of quantification (LOQ, S/N=10) were 0.02 mug/L 
      and 0.1 mug/L, respectively. The relative standard deviations (RSDs) of interday 
      and intraday precisions ranged from 3.3% to 7.9%. The ciprofloxacin recovery was 
      in the range of 92.6%-119.1%. The results showed that the proposed method is 
      simple and fast, with high accuracy and sensitivity, thus being suitable for the 
      rapid detection of trace ciprofloxacin residue in milk samples.
FAU - Tian, Hongjing
AU  - Tian H
AD  - College of Life Science and Biopharmaceutical, Shenyang Pharmaceutical 
      University, Shenyang 110016, China.
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
FAU - Liu, Tong
AU  - Liu T
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
FAU - You, Song
AU  - You S
AD  - College of Life Science and Biopharmaceutical, Shenyang Pharmaceutical 
      University, Shenyang 110016, China.
FAU - Zhang, Feng
AU  - Zhang F
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Polymers)
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Ciprofloxacin/*analysis
MH  - Food Analysis/*methods
MH  - Milk/*chemistry
MH  - *Molecular Imprinting
MH  - Polymers
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - ciprofloxacin
OT  - extraction
OT  - high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
OT  - milk
OT  - molecularly imprinted membrane
EDAT- 2021/07/03 06:00
MHDA- 2021/07/27 06:00
CRDT- 2021/07/02 09:13
PHST- 2021/07/02 09:13 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
AID - 10.3724/SP.J.1123.2020.02017 [doi]
PST - ppublish
SO  - Se Pu. 2020 Jul 8;38(7):775-781. doi: 10.3724/SP.J.1123.2020.02017.