PMID- 34214343
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 2191-0286 (Electronic)
IS  - 0792-6855 (Linking)
VI  - 32
IP  - 4
DP  - 2021 Jun 25
TI  - The thermodynamic study of p-methoxycinnamic acid inclusion complex formation, 
      using beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
PG  - 663-667
LID - 10.1515/jbcpp-2021-0008 [doi]
AB  - OBJECTIVES: Cyclodextrin's ability to form an inclusion complex with a guest 
      molecule is a function of two factors. The first is steric and depends on the 
      relative size of cyclodextrin cavity to the guest molecule, while the second is 
      the thermodynamic interaction between the different system components. This study 
      therefore aims to determine the effect of beta-cyclodextrin and 
      hydroxypropyl-beta-cyclodextrin as complex formers, on thermodynamic parameter 
      values (DeltaH, DeltaG, and DeltaS) in the formation of inclusion complex with 
      p-methoxycinnamic acid (pMCA). METHODS: The pMCA complex formation with 
      beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin was determined in 0.02 pH 4.0 M 
      acetate buffer and 0.02 M pH 7.0 phosphate buffer, with a 0.2 micro value at 32, 37, 
      and 42 +/- 0.5  degrees C. This experiment was carried out in a waterbath shaker until a 
      saturated solution was obtained. Subsequently, pMCA concentration was determined 
      using UV spectrophotometer at the maximum pMCA wavelength, at each pH. RESULTS: 
      The result showed pMCA formed inclusion complex with beta-cyclodextrin or 
      hydroxypropyl-beta-cyclodextrin and exhibited increased solubility with increase in 
      beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin concentration. This temperature 
      rise led to a decrease in the complex's constant stability (K). Furthermore, the 
      interaction showed a negative enthalpy (∆H<0) and is a spontaneous processes 
      (∆G<0). At pH 4.0, an increase in the system's entropy occurred (∆S>0), however, 
      at pH 7.0, the system's entropy decreased (∆S<0). CONCLUSIONS: The rise in pMCA 
      solubility with increase in cyclodextrin solution concentration indicates an 
      inclusion complex has been formed, and is supported by thermodynamic data.
CI  - (c) 2021 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Isadiartuti, Dewi
AU  - Isadiartuti D
AD  - Faculty of Pharmacy, Department of Pharmaceutics, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Rosita, Noorma
AU  - Rosita N
AD  - Faculty of Pharmacy, Department of Pharmaceutics, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Ekowati, Juni
AU  - Ekowati J
AD  - Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Syahrani, Achmad
AU  - Syahrani A
AD  - Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Ariyani, Toetik
AU  - Ariyani T
AD  - Department of Clinical Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
FAU - Rifqi, M Ainur
AU  - Rifqi MA
AD  - Faculty of Pharmacy, Department of Pharmaceutics, Universitas Airlangga, 
      Surabaya, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20210625
PL  - Germany
TA  - J Basic Clin Physiol Pharmacol
JT  - Journal of basic and clinical physiology and pharmacology
JID - 9101750
RN  - 0 (Cyclodextrins)
RN  - 0 (beta-Cyclodextrins)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin/*chemistry
MH  - Cyclodextrins
MH  - Solubility
MH  - Thermodynamics
MH  - beta-Cyclodextrins
OTO - NOTNLM
OT  - hydroxypropyl-beta-cyclodextrin
OT  - inclusion complex
OT  - p-methoxycinnamic acid
OT  - solubility enhancement
OT  - thermodynamic
OT  - beta-cyclodextrin
EDAT- 2021/07/03 06:00
MHDA- 2022/02/15 06:00
CRDT- 2021/07/02 17:26
PHST- 2021/01/06 00:00 [received]
PHST- 2021/03/04 00:00 [accepted]
PHST- 2021/07/02 17:26 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
AID - jbcpp-2021-0008 [pii]
AID - 10.1515/jbcpp-2021-0008 [doi]
PST - epublish
SO  - J Basic Clin Physiol Pharmacol. 2021 Jun 25;32(4):663-667. doi: 
      10.1515/jbcpp-2021-0008.