PMID- 34216098
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 2190-6009 (Electronic)
IS  - 2190-5991 (Print)
IS  - 2190-5991 (Linking)
VI  - 12
IP  - 4
DP  - 2021 Aug
TI  - Relative sit-to-stand power: aging trajectories, functionally relevant cut-off 
      points, and normative data in a large European cohort.
PG  - 921-932
LID - 10.1002/jcsm.12737 [doi]
AB  - BACKGROUND: A validated, standardized, and feasible test to assess muscle power 
      in older adults has recently been reported: the sit-to-stand (STS) muscle power 
      test. This investigation aimed to assess the relationship between relative STS 
      power and age and to provide normative data, cut-off points, and minimal 
      clinically important differences (MCID) for STS power measures in older women and 
      men. METHODS: A total of 9320 older adults (6161 women and 3159 men) aged 
      60-103 years and 586 young and middle-aged adults (318 women and 268 men) aged 
      20-60 years were included in this cross-sectional study. Relative (normalized to 
      body mass), allometric (normalized to height squared), and specific (normalized 
      to legs muscle mass) muscle power values were assessed by the 30 s STS power 
      test. Body composition was evaluated by dual energy X-ray absorptiometry and 
      bioelectrical impedance analysis, and legs skeletal muscle index (SMI; normalized 
      to height squared) was calculated. Habitual and maximal gait speed, timed 
      up-and-go test, and 6 min walking distance were collected as physical performance 
      measures, and participants were classified into two groups: well-functioning and 
      mobility-limited older adults. RESULTS: Relative STS power was found to decrease 
      between 30-50 years (-0.05 W.kg(-1) .year(-1) ; P > 0.05), 50-80 years (-0.10 to 
      -0.13 W.kg(-1) .year(-1) ; P < 0.001), and above 80 years (-0.07 to 
      -0.08 W.kg(-1) .year(-1) ; P < 0.001). A total of 1129 older women (18%) and 510 
      older men (16%) presented mobility limitations. Mobility-limited older adults 
      were older and exhibited lower relative, allometric, and specific power; higher 
      body mass index (BMI) and legs SMI (both only in women); and lower legs SMI (only 
      in men) than their well-functioning counterparts (all P < 0.05). Normative data 
      and cut-off points for relative, allometric, and specific STS power and for BMI 
      and legs SMI were reported. Low relative STS power occurred below 2.1 W.kg(-1) in 
      women (area under the curve, AUC, [95% confidence interval, CI] = 0.85 
      [0.84-0.87]) and below 2.6 W.kg(-1) in men (AUC [95% CI] = 0.89 [0.87-0.91]). The 
      age-adjusted odds ratios [95% CI] for mobility limitations in older women and men 
      with low relative STS power were 10.6 [9.0-12.6] and 14.1 [10.9-18.2], 
      respectively. MCID values for relative STS power were 0.33 W.kg(-1) in women and 
      0.42 W.kg(-1) in men. CONCLUSIONS: Relative STS power decreased significantly 
      after the age of 50 years and was negatively and strongly associated with 
      mobility limitations. Our study provides normative data, functionally relevant 
      cut-off points, and MCID values for STS power for their use in daily clinical 
      practice.
CI  - (c) 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John 
      Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting 
      Disorders.
FAU - Alcazar, Julian
AU  - Alcazar J
AUID- ORCID: 0000-0002-1090-5482
AD  - GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
AD  - Geriatric Research Unit, Geriatric Department, Bispebjerg-Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Alegre, Luis M
AU  - Alegre LM
AUID- ORCID: 0000-0002-4502-9275
AD  - GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
FAU - Van Roie, Evelien
AU  - Van Roie E
AD  - Department of Movement Sciences, Physical Activity, Sports and Health Research 
      Group, KU Leuven, Leuven, Belgium.
FAU - Magalhaes, Joao P
AU  - Magalhaes JP
AD  - Exercise and Health Laboratory, CIPER, Facultade de Motricidade Humana, 
      Universidade de Lisboa, Lisbon, Portugal.
FAU - Nielsen, Barbara R
AU  - Nielsen BR
AD  - Department of Internal Medicine, Geriatric Division, Amager and Hvidovre 
      Hospital, Glostrup, Copenhagen, Denmark.
FAU - Gonzalez-Gross, Marcela
AU  - Gonzalez-Gross M
AD  - ImFine Research Group, Departamento de Salud y Rendimiento Humano, Facultad de 
      Ciencias de la Actividad Fisica y del Deporte, Universidad Politecnica de Madrid, 
      Madrid, Spain.
AD  - CIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
FAU - Judice, Pedro B
AU  - Judice PB
AD  - Exercise and Health Laboratory, CIPER, Facultade de Motricidade Humana, 
      Universidade de Lisboa, Lisbon, Portugal.
FAU - Casajus, Jose A
AU  - Casajus JA
AD  - CIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN), Madrid, Spain.
AD  - Growth, Exercise, Nutrition, and Development Research Group, University of 
      Zaragoza, Zaragoza, Spain.
FAU - Delecluse, Christophe
AU  - Delecluse C
AD  - Department of Movement Sciences, Physical Activity, Sports and Health Research 
      Group, KU Leuven, Leuven, Belgium.
FAU - Sardinha, Luis B
AU  - Sardinha LB
AD  - Exercise and Health Laboratory, CIPER, Facultade de Motricidade Humana, 
      Universidade de Lisboa, Lisbon, Portugal.
FAU - Suetta, Charlotte
AU  - Suetta C
AD  - Geriatric Research Unit, Geriatric Department, Bispebjerg-Frederiksberg 
      University Hospital, Copenhagen, Denmark.
AD  - Department of Clinical Physiology, Nuclear Medicine & PET, 
      Righospitalet-Glostrup, Copenhagen University Hospital, Copenhagen, Denmark.
AD  - Geriatric Research Unit, Department of Internal Medicine, Herlev-Gentofte 
      University Hospital, Herlev, Denmark.
FAU - Ara, Ignacio
AU  - Ara I
AUID- ORCID: 0000-0002-2854-6684
AD  - GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210703
PL  - Germany
TA  - J Cachexia Sarcopenia Muscle
JT  - Journal of cachexia, sarcopenia and muscle
JID - 101552883
SB  - IM
MH  - Aged
MH  - Aging
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Muscle, Skeletal
MH  - *Sarcopenia
PMC - PMC8350203
OTO - NOTNLM
OT  - Chair stand
OT  - Functional ability
OT  - Intrinsic capacity
OT  - Mobility limitations
OT  - Muscle
OT  - Sarcopenia
COIS- The authors declare no competing interests.
EDAT- 2021/07/04 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/08/01
CRDT- 2021/07/03 06:21
PHST- 2021/04/13 00:00 [revised]
PHST- 2020/11/10 00:00 [received]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/07/04 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/07/03 06:21 [entrez]
PHST- 2021/08/01 00:00 [pmc-release]
AID - JCSM12737 [pii]
AID - 10.1002/jcsm.12737 [doi]
PST - ppublish
SO  - J Cachexia Sarcopenia Muscle. 2021 Aug;12(4):921-932. doi: 10.1002/jcsm.12737. 
      Epub 2021 Jul 3.