PMID- 34216238
OWN - NLM
STAT- MEDLINE
DCOM- 20211027
LR  - 20211116
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 128
IP  - 8
DP  - 2021 Aug
TI  - The language profile in multiple system atrophy: an exploratory study.
PG  - 1195-1203
LID - 10.1007/s00702-021-02372-6 [doi]
AB  - BACKGROUND: The evidence about the language performance profile of multiple 
      system atrophy (MSA) is limited, but its definition may lead to a more 
      comprehensive characterization of the disorder and contribute to clarify the 
      involvement of the basal ganglia in language abilities. OBJECTIVE: The objectives 
      of the study were: (1) to evaluate the reliability of the Screening for Aphasia 
      in NeuroDegeneration (SAND) in MSA patients; (2) compare the linguistic profiles 
      among MSA and Parkinson's disease (PD) patients and healthy controls (HC), and 
      (3) assess relationships between language impairment and cognitive status and MSA 
      motor subtypes. METHODS AND RESULTS: Forty patients with a diagnosis of MSA, 22 
      HC and 17 patients with PD were enrolled in the present study. By excluding the 
      writing task that showed a poor acceptability, we showed that the MSA-tailored 
      SAND Global Score is an acceptable, consistent and reliable tool to screen 
      language disturbances in MSA. MSA patients performed worse than HC, but not than 
      PD, in MSA-tailored SAND Global Score, repetition, reading and semantic 
      association tasks. We did not find significant differences between MSA 
      phenotypes. MSA patients with mild cognitive impairment-multiple domain presented 
      worse language performances as compared to MSA patients with normal cognition and 
      mild cognitive impairment-single domain. CONCLUSION: The MSA-tailored SAND Global 
      Score is a consistent and reliable tool to screen language disturbances in MSA. 
      Language disturbances characterize MSA patients irrespective of disease 
      phenotype, and parallel the decline of global cognitive functions.
CI  - (c) 2021. The Author(s).
FAU - Cuoco, Sofia
AU  - Cuoco S
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy.
FAU - Picillo, Marina
AU  - Picillo M
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy.
FAU - Carotenuto, Immacolata
AU  - Carotenuto I
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy.
FAU - Erro, Roberto
AU  - Erro R
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy.
FAU - Catricala, Eleonora
AU  - Catricala E
AD  - University School for Advanced Studies IUSS Pavia, Pavia, Italy.
FAU - Cappa, Stefano
AU  - Cappa S
AD  - University School for Advanced Studies IUSS Pavia, Pavia, Italy.
AD  - IRCCS Fondazione Mondino, Pavia, Italy.
FAU - Pellecchia, Maria Teresa
AU  - Pellecchia MT
AUID- ORCID: 0000-0002-6217-313X
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy. mpellecchia@unisa.it.
FAU - Barone, Paolo
AU  - Barone P
AD  - Neuroscience Section, Department of Medicine, Surgery and Dentistry, Center for 
      Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210703
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Cognition
MH  - *Cognitive Dysfunction/diagnosis/etiology
MH  - Humans
MH  - *Multiple System Atrophy/complications/diagnosis
MH  - *Parkinson Disease/complications/diagnosis
MH  - Reproducibility of Results
PMC - PMC8322009
OTO - NOTNLM
OT  - Cognition
OT  - Language
OT  - Mild cognitive impairment
OT  - Multiple System Atrophy
EDAT- 2021/07/04 06:00
MHDA- 2021/10/28 06:00
PMCR- 2021/07/03
CRDT- 2021/07/03 12:07
PHST- 2021/03/29 00:00 [received]
PHST- 2021/06/20 00:00 [accepted]
PHST- 2021/07/04 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/07/03 12:07 [entrez]
PHST- 2021/07/03 00:00 [pmc-release]
AID - 10.1007/s00702-021-02372-6 [pii]
AID - 2372 [pii]
AID - 10.1007/s00702-021-02372-6 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2021 Aug;128(8):1195-1203. doi: 
      10.1007/s00702-021-02372-6. Epub 2021 Jul 3.