PMID- 34217037 OWN - NLM STAT- MEDLINE DCOM- 20210902 LR - 20210902 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 156 DP - 2021 Nov TI - Joint effect of urinary arsenic species and serum one-carbon metabolism nutrients on gestational diabetes mellitus: A cross-sectional study of Chinese pregnant women. PG - 106741 LID - S0160-4120(21)00366-4 [pii] LID - 10.1016/j.envint.2021.106741 [doi] AB - BACKGROUND: Growing evidence indicates that arsenic (As) exposure can increase the risk of gestational diabetes mellitus (GDM). However, little is known about As species and GDM and the combined effect of As and one-carbon metabolism (OCM) on GDM. OBJECTIVES: We aimed to examine the associations between As species and GDM and evaluate the potential interactions of folate, vitamin B(12), and homocysteine (Hcy) with As species on GDM prevalence. METHOD: We measured levels of arsenite (As(3+)), arsenate (As(5+)), dimethylarsinic acid (DMA), and arsenobetaine (AsB) species in urine and folate, vitamin B(12), and Hcy in serum from 396 pregnant women in Tianjin, China. The diagnosis of GDM was based on an oral glucose tolerance test. Associations of As species in urine with GDM were evaluated using generalized linear models (GLMs) and Bayesian kernel machine regression (BKMR). Additive interactions of As and OCM with GDM were estimated by determining the relative excess risk due to interaction (RERI). RESULTS: Of the 396 pregnant women, 89 were diagnosed with GDM. Continuous increases in urinary inorganic As were associated with GDM in the GLMs, with adjusted odds ratios of 2.12 (95% CI: 0.96, 4.71) for As(3+), and 0.27 (95% CI: 0.07, 0.98) for As(5+). The BKMR in estimating the exposure-response functions showed that As(3+) and AsB were positively associated with GDM. However, As(5+) showed a negative relationship with GDM. Although the additive interactions between As exposure and OCM indicators were not significant, we found that pregnant women with higher urinary As(3+) and total As accompanied by lower serum vitamin B(12) were more likely to have higher odds of GDM (3.12, 95% CI: 1.32, 7.38 and 3.10, 95% CI: 1.30, 7.38, respectively). CONCLUSIONS: Our data suggest a positive relation between As(3+) and GDM but a negative relation between As(5+) and GDM. Potential additive interaction of As and OCM with GDM requires further investigation. CI - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Zhang, Qiang AU - Zhang Q AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Xumei AU - Zhang X AD - Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Li, Shuying AU - Li S AD - Department of Endocrinology, Tianjin Xiqing Hospital, Tianjin 300380, China. FAU - Liu, Huihuan AU - Liu H AD - Beichen District Women's and Children's Health Center, Tianjin 300400, China. FAU - Liu, Liangpo AU - Liu L AD - School of Public Health, Shanxi Medical University, Taiyuan 030001 China. FAU - Huang, Qingyu AU - Huang Q AD - Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. FAU - Hou, Yaxing AU - Hou Y AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Liang, Xiaoshan AU - Liang X AD - Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Cui, Bo AU - Cui B AD - Institute of Environmental and Operational Medicine, Academy of Military Medical Sciences, Tianjin 300050, China. FAU - Zhang, Ming AU - Zhang M AD - Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China. FAU - Xia, Liting AU - Xia L AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Liwen AU - Zhang L AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Li, Chen AU - Li C AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Li, Jing AU - Li J AD - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China. FAU - Sun, Guifan AU - Sun G AD - Key Laboratory of Arsenic-related Biological Effects and Prevention and Treatment in Liaoning Province, School of Public Health, China Medical University, Shenyang 110122, China. FAU - Tang, Naijun AU - Tang N AD - Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China. Electronic address: tangnaijun@tmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210630 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 7440-44-0 (Carbon) RN - N712M78A8G (Arsenic) SB - IM MH - *Arsenic MH - Bayes Theorem MH - Carbon MH - China/epidemiology MH - Cross-Sectional Studies MH - *Diabetes, Gestational/epidemiology MH - Female MH - Humans MH - Nutrients MH - Pregnancy MH - Pregnant Women OTO - NOTNLM OT - Arsenic OT - Diabetes OT - Folate OT - Synergistic effect OT - Vitamin B(12) EDAT- 2021/07/04 06:00 MHDA- 2021/09/03 06:00 CRDT- 2021/07/03 20:23 PHST- 2021/01/19 00:00 [received] PHST- 2021/05/06 00:00 [revised] PHST- 2021/06/24 00:00 [accepted] PHST- 2021/07/04 06:00 [pubmed] PHST- 2021/09/03 06:00 [medline] PHST- 2021/07/03 20:23 [entrez] AID - S0160-4120(21)00366-4 [pii] AID - 10.1016/j.envint.2021.106741 [doi] PST - ppublish SO - Environ Int. 2021 Nov;156:106741. doi: 10.1016/j.envint.2021.106741. Epub 2021 Jun 30.