PMID- 34217720
OWN - NLM
STAT- MEDLINE
DCOM- 20211222
LR  - 20211222
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Linking)
VI  - 239
DP  - 2021 Sep
TI  - Function and therapeutic potential of N-acyl amino acids.
PG  - 105114
LID - S0009-3084(21)00067-0 [pii]
LID - 10.1016/j.chemphyslip.2021.105114 [doi]
AB  - N-acyl amino acids (NAAs) are amphiphilic molecules, with different potential 
      fatty acid and head group moieties. NAAs are the largest family of anandamide 
      congener lipids discovered to date. In recent years, several NAAs have been 
      identified as potential ligands, engaging novel binding sites and mechanisms for 
      modulation of membrane proteins such as G-protein coupled receptors (GPRs), 
      nuclear receptors, ion channels, and transporters. NAAs play a key role in a 
      variety of physiological functions as lipid signaling molecules. Understanding 
      the structure, function roles, and pharmacological potential of these NAAs is 
      still in its infancy, and the biochemical roles are also mostly unknown. This 
      review will provide a summary of the literature on NAAs and emphasize their 
      therapeutic potential.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Arul Prakash, Sukanya
AU  - Arul Prakash S
AD  - Department of Chemistry, School of Advanced Sciences, VIT, Vellore, 632014, TN, 
      India.
FAU - Kamlekar, Ravi Kanth
AU  - Kamlekar RK
AD  - Department of Chemistry, School of Advanced Sciences, VIT, Vellore, 632014, TN, 
      India. Electronic address: ravikanth.k@vit.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210702
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Amino Acids)
RN  - 0 (Appetite Depressants)
RN  - 0 (Ion Channels)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Acylation
MH  - Amino Acids/*chemistry/metabolism/therapeutic use
MH  - Animals
MH  - Appetite Depressants/chemistry/therapeutic use
MH  - Ion Channels/chemistry/metabolism
MH  - Obesity/drug therapy
MH  - Receptors, Cytoplasmic and Nuclear/chemistry/metabolism
MH  - Receptors, G-Protein-Coupled/chemistry/metabolism
OTO - NOTNLM
OT  - G-protein coupled receptor
OT  - N-acyl amino acid
OT  - N-acylglycine
OT  - N-acylserine
OT  - N-acyltaurine
EDAT- 2021/07/05 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/07/04 20:38
PHST- 2021/02/02 00:00 [received]
PHST- 2021/06/06 00:00 [revised]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/07/05 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/07/04 20:38 [entrez]
AID - S0009-3084(21)00067-0 [pii]
AID - 10.1016/j.chemphyslip.2021.105114 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2021 Sep;239:105114. doi: 10.1016/j.chemphyslip.2021.105114. 
      Epub 2021 Jul 2.