PMID- 34217772
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 178
DP  - 2021 Aug
TI  - Kinetics of C-peptide during mixed meal test and its value for treatment 
      optimization in monogenic diabetes patients.
PG  - 108938
LID - S0168-8227(21)00298-9 [pii]
LID - 10.1016/j.diabres.2021.108938 [doi]
AB  - AIM: The mixed meal tolerance test (MMTT) is a gold standard for evaluating 
      beta-cell function. There is limited data on MMTT in monogenic diabetes (MD). 
      Therefore, we aimed to analyze plasma C-peptide (CP) kinetics during MMTT in 
      young MODY and neonatal diabetes patients as a biomarker for beta-cell function. 
      METHODS: We included 41 patients with MD diagnosis (22 GCK, 8 HNF1A, 3 HNF4A, 4 
      KCNJ11, 2 ABCC8, 1 INS, 1 KLF11). Standardized 3-hour MMTT with glycemia and 
      plasma CP measurements were performed for all individuals. Pancreatic beta-cell 
      response was assessed by the area under the curve CP (AUC(CP)), the baseline CP 
      (CP(Base)) and the peak CP (CP(max)). Threshold points of CP(Base), CP(90), 
      CP(max) and CP(AUC) were determined from analysis of ROC curves. RESULTS: GCK 
      diabetes patients had significantly higher AUC(CP), CP(Base) and CP(max) compared 
      to HNF4A and KCNJ11 patients. In HNF4A, KCNJ11 and ABCC8 patients with all CP 
      levels < 200 pmol/L, the treatment change attempt to sulfonylurea agent was 
      unsuccessful. The ROC analysis showed that CP baseline threshold equal or higher 
      to 133.5 pmol/L could be used to predict successful switch to oral agents. 
      CONCLUSION: A pretreatment challenge with MMTT might be used to guide the optimal 
      treatment after molecular diagnosis of MD.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Stankute, Ingrida
AU  - Stankute I
AD  - Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 
      Kaunas, Lithuania. Electronic address: ingrida.stankute@lsmuni.lt.
FAU - Verkauskiene, Rasa
AU  - Verkauskiene R
AD  - Institute of Endocrinology, Lithuanian University of Health Sciences, Eiveniu 2, 
      LT-50161 Kaunas, Lithuania.
FAU - Dobrovolskiene, Rimante
AU  - Dobrovolskiene R
AD  - Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 
      Kaunas, Lithuania.
FAU - Danyte, Evalda
AU  - Danyte E
AD  - Institute of Endocrinology, Lithuanian University of Health Sciences, Eiveniu 2, 
      LT-50161 Kaunas, Lithuania.
FAU - Jasinskiene, Edita
AU  - Jasinskiene E
AD  - Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 
      Kaunas, Lithuania.
FAU - Mockeviciene, Giedre
AU  - Mockeviciene G
AD  - Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 
      Kaunas, Lithuania.
FAU - Schwitzgebel, Valerie M
AU  - Schwitzgebel VM
AD  - Pediatric Endocrine and Diabetes Unit, Department of Pediatrics, Gynecology and 
      Obstetrics, University Hospitals of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Center of the Faculty of Medicine, University of Geneva, 1211 Geneva, 
      Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
SB  - IM
MH  - Blood Glucose
MH  - C-Peptide
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Kinetics
MH  - Meals
OTO - NOTNLM
OT  - Beta-cell function
OT  - C-peptide
OT  - Mixed meal tolerance
OT  - Monogenic diabetes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/07/05 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/07/04 20:39
PHST- 2021/02/01 00:00 [received]
PHST- 2021/06/12 00:00 [revised]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/07/05 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/07/04 20:39 [entrez]
AID - S0168-8227(21)00298-9 [pii]
AID - 10.1016/j.diabres.2021.108938 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 Aug;178:108938. doi: 10.1016/j.diabres.2021.108938. 
      Epub 2021 Jul 1.