PMID- 34218166
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 186
DP  - 2021 Sep
TI  - The longitudinal use of EmPHasis-10 and CAMPHOR questionnaire health-related 
      quality of life scores in patients with pulmonary arterial hypertension and 
      chronic thromboembolic pulmonary hypertension.
PG  - 106525
LID - S0954-6111(21)00231-6 [pii]
LID - 10.1016/j.rmed.2021.106525 [doi]
AB  - BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with 
      pulmonary hypertension (PH). The EmPHasis-10 and CAMPHOR questionnaires are 
      developed to evaluate HRQoL specifically in patients with PH. Data on the 
      longitudinal use of both questionnaires are still limited. We evaluated the 
      longitudinal value of both questionnaires and established minimal clinically 
      important differences (MCID). METHODS: Sixty-one treatment naive pulmonary 
      arterial hypertension or chronic thromboembolic patients were prospectively 
      included. Patients were treated according to the current ESC/ERS guidelines. We 
      compared EmPHasis-10 and CAMPHOR scores between baseline, 6 and 12 months of 
      follow-up and evaluated the correlation between these scores and a 5-scale 
      symptom severity score, 5-scale overall health score, NYHA-classification, 6 min 
      walk test distance (6MWD), NT-proBNP and echocardiographic parameters. RESULTS: 
      After one year of treatment a significant reduction in EmPHasis-10 score and 
      CAMPHOR QoL and symptoms domain score was observed. Moderate to good correlations 
      were observed between the questionnaires and the overall-health and symptom 
      severity score and 6MWD. No relevant correlations were seen between the 
      questionnaires and NT-pro-BNP and echocardiographic parameters. EmPHasis-10 
      scores showed strong correlations with all CAMPHOR domains. The MCID for the 
      EmPHasis-10 questionnaire was -8. The MCIDs for the CAMPHOR domains were: 
      activity -3, symptoms -4, QoL -3. CONCLUSION: The EmPHasis-10 and CAMPHOR 
      questionnaires are valid tools for the longitudinal measurement of HRQoL in 
      patients with PH. The much shorter EmPHasis-10 correlates well with the CAMPHOR 
      domain scores and with the clinical endpoints and it may be easier to use in 
      daily practice.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Hendriks, Paul M
AU  - Hendriks PM
AD  - Department of Respiratory Medicine, Erasmus MC, University Medical Centre 
      Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands; 
      Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Doctor 
      Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
FAU - van Thor, Mitch C J
AU  - van Thor MCJ
AD  - Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435CM 
      Nieuwegein, the Netherlands.
FAU - Wapenaar, Monique
AU  - Wapenaar M
AD  - Department of Respiratory Medicine, Erasmus MC, University Medical Centre 
      Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
FAU - Chandoesing, Prewesh
AU  - Chandoesing P
AD  - Department of Respiratory Medicine, Erasmus MC, University Medical Centre 
      Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
FAU - van den Toorn, Leon M
AU  - van den Toorn LM
AD  - Department of Respiratory Medicine, Erasmus MC, University Medical Centre 
      Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
FAU - van den Bosch, Annemien E
AU  - van den Bosch AE
AD  - Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Doctor 
      Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
FAU - Post, Marco C
AU  - Post MC
AD  - Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435CM 
      Nieuwegein, the Netherlands; Department of Cardiology, Utrecht University Medical 
      Center, Heidelberglaan 100, 3584CX Utrecht, the Netherlands.
FAU - Boomars, Karin A
AU  - Boomars KA
AD  - Department of Respiratory Medicine, Erasmus MC, University Medical Centre 
      Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands. 
      Electronic address: k.boomars@erasmusmc.nl.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210629
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Patient Reported Outcome Measures
MH  - Peptide Fragments/blood
MH  - *Pulmonary Arterial Hypertension/diagnosis/physiopathology
MH  - *Pulmonary Embolism/diagnosis/physiopathology
MH  - *Quality of Life
MH  - *Surveys and Questionnaires
MH  - Time Factors
MH  - Walk Test
OTO - NOTNLM
OT  - Chronic thromboembolic pulmonary hypertension
OT  - Health related quality of life
OT  - Patient reported outcomes
OT  - Pulmonary arterial hypertension
OT  - Quality of life
EDAT- 2021/07/05 06:00
MHDA- 2022/02/08 06:00
CRDT- 2021/07/04 20:59
PHST- 2021/03/25 00:00 [received]
PHST- 2021/06/11 00:00 [revised]
PHST- 2021/06/26 00:00 [accepted]
PHST- 2021/07/05 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/07/04 20:59 [entrez]
AID - S0954-6111(21)00231-6 [pii]
AID - 10.1016/j.rmed.2021.106525 [doi]
PST - ppublish
SO  - Respir Med. 2021 Sep;186:106525. doi: 10.1016/j.rmed.2021.106525. Epub 2021 Jun 
      29.