PMID- 34218229
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20220302
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 99
IP  - 6
DP  - 2021
TI  - Rescue Anterior Capsulotomy after Failure of Nucleus Accumbens Deep Brain 
      Stimulation in Anorexia Nervosa: A Case Report.
PG  - 491-495
LID - 10.1159/000517105 [doi]
AB  - Anorexia nervosa (AN) is a highly disabling mental disorder with high rates of 
      morbidity and mortality. Few psychological treatments and pharmacotherapy are 
      proven to be effective for adult AN. Two invasive stereotactic neurosurgical 
      interventions, deep brain stimulation (DBS) and anterior capsulotomy, are now 
      commonly used as investigational approaches for the treatment of AN. Here, we 
      report the long-term safety and efficacy of rescue bilateral anterior capsulotomy 
      after the failure of bilateral nucleus accumbens (NAcc)-DBS in an 18-year-old 
      female patient with life-threatening and treatment-resistant restricting subtype 
      AN. Improvements in the neuropsychiatric assessment were not documented 6 months 
      after the NAcc-DBS. Rescue bilateral anterior capsulotomy was proposed and 
      performed, resulting in a long-lasting restoration of body weight and a 
      significant and sustained remission in AN core symptoms. The DBS pulse generator 
      was exhausted 2 years after capsulotomy and removed 3 years postoperatively. No 
      relapse was reported at the last follow-up (7 years after the first 
      intervention). From this case, we suggest that capsulotomy could be a rescue 
      treatment for patients with treatment-resistant AN after NAcc-DBS failure. 
      Further well-controlled studies are warranted to validate our findings.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Lin, Zhengyu
AU  - Lin Z
AD  - Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China, hrfrerrare@sjtu.edu.cn.
AD  - Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China, hrfrerrare@sjtu.edu.cn.
FAU - Dai, Lulin
AU  - Dai L
AD  - Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Chencheng
AU  - Zhang C
AD  - Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Li, Dianyou
AU  - Li D
AD  - Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Sun, Bomin
AU  - Sun B
AD  - Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
LA  - eng
PT  - Case Reports
DEP - 20210702
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Anorexia Nervosa/psychology/surgery
MH  - *Deep Brain Stimulation/methods
MH  - Female
MH  - Humans
MH  - Neurosurgical Procedures/methods
MH  - Nucleus Accumbens/surgery
OTO - NOTNLM
OT  - Anorexia nervosa
OT  - Anterior capsulotomy
OT  - Case report
OT  - Deep brain stimulation
OT  - Nucleus accumbens
EDAT- 2021/07/05 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/07/04 21:02
PHST- 2021/03/26 00:00 [received]
PHST- 2021/04/30 00:00 [accepted]
PHST- 2021/07/05 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/07/04 21:02 [entrez]
AID - 000517105 [pii]
AID - 10.1159/000517105 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2021;99(6):491-495. doi: 10.1159/000517105. Epub 2021 
      Jul 2.