PMID- 34218659
OWN - NLM
STAT- MEDLINE
DCOM- 20210810
LR  - 20210901
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 55
IP  - 14
DP  - 2021 Jul 20
TI  - Internal and Maternal Distribution of Persistent Organic Pollutants in Sea Turtle 
      Tissues: A Meta-Analysis.
PG  - 10012-10024
LID - 10.1021/acs.est.1c02845 [doi]
AB  - We aimed to identify patterns in the internal distribution of persistent organic 
      pollutants (POPs) and assess contributing factors using sea turtles and their 
      offspring as a case study of a long-lived wildlife species. We systematically 
      synthesized 40 years of data and developed a lipid database to test whether 
      lipid-normalized POP concentrations are equal among tissues as expected under 
      steady state for lipophilic compounds. Results supported equal partitioning among 
      tissues with high blood flow or perfusion including the heart, kidney, muscle, 
      and lung. Observed differences in the brain, fat, and blood plasma, however, 
      suggest the physiological influence of the blood-brain barrier, limited 
      perfusion, and protein content, respectively. Polybrominated diphenyl ethers 
      partitioned comparably to legacy POPs. Polycyclic aromatic hydrocarbons, 
      meanwhile, partitioned more into the lung, colon, and muscle compared to the 
      liver under chronic and acute field exposure. Partitioning ratios of individual 
      POPs among tissues were significantly related to the lipophilicity of compounds 
      (as estimated by K(ow)) in half of the observed cases, and significant 
      differences between juveniles and adults underscore physiological differences 
      across life stages. The comprehensive tissue partitioning patterns presented here 
      provide a quantitative basis to support comparative assessments of POP pollution 
      derived from biomonitoring among multiple tissues.
FAU - Munoz, Cynthia C
AU  - Munoz CC
AUID- ORCID: 0000-0003-3805-8091
AD  - Department of Environmental Science, Institute for Water and Wetland Research, 
      Radboud University, 6500 GL Nijmegen, The Netherlands.
FAU - Hendriks, A Jan
AU  - Hendriks AJ
AD  - Department of Environmental Science, Institute for Water and Wetland Research, 
      Radboud University, 6500 GL Nijmegen, The Netherlands.
FAU - Ragas, Ad M J
AU  - Ragas AMJ
AD  - Department of Environmental Science, Institute for Water and Wetland Research, 
      Radboud University, 6500 GL Nijmegen, The Netherlands.
FAU - Vermeiren, Peter
AU  - Vermeiren P
AD  - Department of Environmental Science, Institute for Water and Wetland Research, 
      Radboud University, 6500 GL Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210704
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Environmental Monitoring
MH  - *Environmental Pollutants/analysis
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
MH  - *Turtles
MH  - *Water Pollutants, Chemical
PMC - PMC8382251
OTO - NOTNLM
OT  - chemical partitioning
OT  - diffusion limitation
OT  - fugacity capacity
OT  - lipophilicity
OT  - maternal transfer
OT  - pollution biomonitoring
OT  - tissue affinity
OT  - tissue physiology
OT  - tissue residue
COIS- The authors declare no competing financial interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/08/11 06:00
PMCR- 2021/08/23
CRDT- 2021/07/05 05:16
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/08/11 06:00 [medline]
PHST- 2021/07/05 05:16 [entrez]
PHST- 2021/08/23 00:00 [pmc-release]
AID - 10.1021/acs.est.1c02845 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2021 Jul 20;55(14):10012-10024. doi: 
      10.1021/acs.est.1c02845. Epub 2021 Jul 4.