PMID- 34219191
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20211214
IS  - 1573-7446 (Electronic)
IS  - 0165-7380 (Linking)
VI  - 45
IP  - 4
DP  - 2021 Dec
TI  - Cloves (Syzygium aromaticum) fluid gel on healing of pododermatitis in rabbits.
PG  - 293-304
LID - 10.1007/s11259-021-09810-6 [doi]
AB  - Wounds are damaging to quality life of confined animals, causing dysfunction in 
      spinal, members injuries, and reduction in productive performance. This research 
      investigated the clove antimicrobial and antioxidant activity on the healing of 
      decubitus wounds (pododermatitis) of rabbits (Oryctolagus cuniculus). Adult 
      animals were treated for 21 days every three days with a fluid gel spray in the 
      wound region: control fluid gel without addition of clove (FGC0), fluid gel with 
      addition of 1% clove powder (FGC1), and fluid gel with 2% clove powder (FGC2). 
      Microbiological analysis for Escherichia coli and Pseudomonas spp. were performed 
      during 21 days of experimental period. After this period, samples from treated 
      skin were evaluated for histological analysis and evaluation of the healing 
      process by spectroscopy (FTIR-ATR). Rabbits treated with FGC2 showed advanced 
      healing and decreased tissue inflammation similar to healthy rabbits, while FGC0 
      rabbits showed a decrease in bacterial contamination without signs of healing. 
      Both FGC1 and FGC2 rabbits demonstrated antimicrobial and antioxidant action 
      against both bacteria tested, favoring the wound healing process. Considering the 
      results, the use of fluid gel with 2% of clove powder (Syzigium aromaticum) based 
      on the best antimicrobial, antioxidant and anti-inflammatory activities on 
      healing of decubitus wounds (pododermatitis) of rabbits in commercial farming 
      system.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Plefh, A C V
AU  - Plefh ACV
AD  - Animal Science Graduate Program, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
FAU - Hoshino, L V C
AU  - Hoshino LVC
AD  - Departamento de Fisica, Universidade Estadual de Maringa, Maringa, PR, 87020-900, 
      Brazil.
FAU - Sato, F
AU  - Sato F
AD  - Departamento de Fisica, Universidade Estadual de Maringa, Maringa, PR, 87020-900, 
      Brazil.
FAU - Castilha, L D
AU  - Castilha LD
AD  - Animal Science Graduate Program, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
AD  - Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
FAU - Santos, T C
AU  - Santos TC
AD  - Animal Science Graduate Program, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
AD  - Departamento de Zootecnia, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
FAU - Vital, A C P
AU  - Vital ACP
AD  - Animal Science Graduate Program, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil.
FAU - Matumoto-Pintro, P T
AU  - Matumoto-Pintro PT
AD  - Animal Science Graduate Program, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil. ptmpintro@uem.br.
AD  - Departamento de Agronomia, Universidade Estadual de Maringa, Maringa, PR, 
      87020-900, Brazil. ptmpintro@uem.br.
LA  - eng
PT  - Journal Article
DEP - 20210705
PL  - Switzerland
TA  - Vet Res Commun
JT  - Veterinary research communications
JID - 8100520
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Gels)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Dermatitis/etiology/prevention & control/veterinary
MH  - Female
MH  - Foot Diseases/etiology/prevention & control/*veterinary
MH  - Gels/*therapeutic use
MH  - Male
MH  - Plant Extracts/chemistry/pharmacology
MH  - Pressure Ulcer/etiology/prevention & control/*veterinary
MH  - *Rabbits/injuries
MH  - Syzygium/*chemistry
MH  - Wound Healing
OTO - NOTNLM
OT  - Epidermis
OT  - Infections
OT  - Inflammation
OT  - Injuries
OT  - Skin
OT  - Wounds
EDAT- 2021/07/06 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/07/05 05:35
PHST- 2021/03/31 00:00 [received]
PHST- 2021/06/23 00:00 [accepted]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/07/05 05:35 [entrez]
AID - 10.1007/s11259-021-09810-6 [pii]
AID - 10.1007/s11259-021-09810-6 [doi]
PST - ppublish
SO  - Vet Res Commun. 2021 Dec;45(4):293-304. doi: 10.1007/s11259-021-09810-6. Epub 
      2021 Jul 5.