PMID- 34219334
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20210906
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 47
IP  - 9
DP  - 2021 Sep
TI  - Malignant struma ovarii: From case to analysis.
PG  - 3339-3351
LID - 10.1111/jog.14902 [doi]
AB  - AIM: To evaluate the clinico-pathologic features, treatment options, prognostic 
      factors, and survival outcomes of malignant struma ovarii based on a systematic 
      literature review in association with our case study. METHODS: A systematic 
      review of the medical literature was performed to identify articles about 
      malignant struma ovarii from January 1983 until July 2020. We evaluated 178 
      cases. RESULTS: The 5-year progression-free survival (PFS) and overall survival 
      (OS) of the entire cohort was 72.5% and 91%, respectively. In univariate 
      analysis, younger age (<43 years), whole strumal cyst diameter >95 mm, presence 
      of a histologic type other than papillary classic-type thyroid carcinoma within 
      the tumor and lymphovascular space invasion were related to poor PFS. Patients 
      who received radioactive iodine ablation (RIA) before the treatment failure had 
      significantly higher PFS than those who did not receive RIA (94.9% vs. 64.8%, 
      p = 0.041, respectively). In univariate analysis, PFS was significantly higher in 
      patients who underwent gynecologic surgery followed by thyroidectomy and RIA 
      compared with those who had surgical treatment only (94.5% vs. 64.3%, p = 0.05, 
      respectively). However, this result could not be identified as an independent 
      prognostic factor in multivariate analysis (p = 0.207). Younger age and absence 
      of capsular involvement were related to significantly increased OS. Histologic 
      type was the only independent prognostic factor for PFS (hazard ratio: 3.30, 95% 
      confidence interval: 1.122-9.748; p = 0.030) CONCLUSION: The most common 
      histologic subtype was the papillary classic type. The presence of a histologic 
      type other than the classic papillary thyroid carcinoma within the tumor was an 
      independent adverse prognostic factor.
CI  - (c) 2021 Japan Society of Obstetrics and Gynecology.
FAU - Ayhan, Sevgi
AU  - Ayhan S
AUID- ORCID: 0000-0002-5556-6154
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Kilic, Fatih
AU  - Kilic F
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Ersak, Burak
AU  - Ersak B
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Aytekin, Okan
AU  - Aytekin O
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Akar, Serra
AU  - Akar S
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Turkmen, Osman
AU  - Turkmen O
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Akgul, Giray
AU  - Akgul G
AD  - Department of Surgical Oncology, Gulhane Education and Research Hospital, Ankara, 
      Turkey.
FAU - Toyran, Atahan
AU  - Toyran A
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Turan, Taner
AU  - Turan T
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
FAU - Kimyon Comert, Gunsu
AU  - Kimyon Comert G
AD  - Department of Gynecologic Oncology, Ankara City Hospital, University of Health 
      Sciences, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20210704
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Iodine Radioisotopes)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes/therapeutic use
MH  - *Ovarian Neoplasms/surgery/therapy
MH  - *Struma Ovarii/diagnosis/surgery
MH  - *Thyroid Neoplasms/surgery/therapy
MH  - Thyroidectomy
OTO - NOTNLM
OT  - malignant struma ovarii
OT  - ovarian cancer
OT  - papillary thyroid carcinoma
OT  - radioactive iodine
OT  - thyroidectomy
EDAT- 2021/07/06 06:00
MHDA- 2021/09/07 06:00
CRDT- 2021/07/05 05:46
PHST- 2021/05/22 00:00 [revised]
PHST- 2020/11/30 00:00 [received]
PHST- 2021/06/06 00:00 [accepted]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
PHST- 2021/07/05 05:46 [entrez]
AID - 10.1111/jog.14902 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2021 Sep;47(9):3339-3351. doi: 10.1111/jog.14902. Epub 
      2021 Jul 4.