PMID- 34220006
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 36
IP  - 3
DP  - 2021 Jul
TI  - Association of TCF7L2 rs7903146 Polymorphism with the Risk of Type 2 Diabetes 
      Mellitus (T2DM) Among Kurdish Population in Erbil Province, Iraq.
PG  - 312-318
LID - 10.1007/s12291-020-00904-7 [doi]
AB  - The genetic predispositions responsible for developing type 2 diabetes mellitus 
      (T(2)DM) in the Middle East are poorly understood. The rs7903146 single 
      nucleotide polymorphism (SNP) located in transcription factor 7-like-2 (TCF7L2) 
      gene has been recognized to have a vital role in the development of T(2)DM 
      disorder. The current study is the first to have researched the possible 
      association between TCF7L2 rs7903146 SNP and T(2)DM among Kurdish population in 
      Kurdistan region of Iraq. The study included 212 participants, half of them were 
      T(2)DM patients, and the other half were disease-free and normoglycemic controls. 
      Genotyping was performed by using a high throughput cost and time effective 
      tetra-primer amplification refractory mutation system-polymerase chain reaction 
      (Tetra ARMS-PCR) assay. The rs7903146 genotypic frequencies for CC, CT and TT 
      were 24.5%, 69.8%, and 5.7% in T(2)DM group respectively, and for the controls 
      were 45.3%, 50.9%, and 3.8% respectively. The frequency of CT genotype was found 
      significantly higher in the cases when compared to the controls (OR = 2.53, 95% 
      CI 1.40-4.57, P value < 0.0019), which indicated that the genotype CT showed risk 
      with diabetes. The T allele showed a high significant frequency in the patients 
      compared to the controls (OR = 1.65, 95% CI 1.10-2.47, P value = 0.014). Our 
      findings demonstrated that the T allele could be a risk factor for increasing the 
      susceptibility of T(2)DM incidence among the Iraqi Kurdish population.
CI  - (c) Association of Clinical Biochemists of India 2020.
FAU - Mustafa, Suhad
AU  - Mustafa S
AUID- ORCID: 0000-0002-6774-2979
AD  - General Directorate for Scientific Research, Salahaddin University- Erbil, Erbil, 
      Kurdistan Region Iraq. GRID: grid.444950.8
FAU - Younus, Delan
AU  - Younus D
AUID- ORCID: 0000-0001-7323-5028
AD  - General Directorate for Scientific Research, Salahaddin University- Erbil, Erbil, 
      Kurdistan Region Iraq. GRID: grid.444950.8
LA  - eng
PT  - Journal Article
DEP - 20200613
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC8215002
OTO - NOTNLM
OT  - Single nucleotide polymorphism
OT  - TCF7L2
OT  - Tetra ARMS-PCR
OT  - Type 2 diabetes mellitus (T2DM)
OT  - rs7903146
COIS- Conflict of interestThe authors declare no conflict of interest with respect to 
      the current study.
EDAT- 2021/07/06 06:00
MHDA- 2021/07/06 06:01
PMCR- 2022/07/01
CRDT- 2021/07/05 09:54
PHST- 2020/03/25 00:00 [received]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2021/07/05 09:54 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/07/06 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 904 [pii]
AID - 10.1007/s12291-020-00904-7 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2021 Jul;36(3):312-318. doi: 10.1007/s12291-020-00904-7. 
      Epub 2020 Jun 13.