PMID- 34220008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 36
IP  - 3
DP  - 2021 Jul
TI  - No Association Between a Genetic Variant of FOXO3 and Risk of Type 2 Diabetes 
      Mellitus in the Elderly Population of North India.
PG  - 330-336
LID - 10.1007/s12291-020-00917-2 [doi]
AB  - Aging can be considered an evolutionary process that is modulated by various 
      genetic and biochemical processes. Therefore the genetic variants may interplay a 
      role in human longevity as well as age related illness. Forkhead Box O (FOXO) 
      gene is one of the major defensive genes that are known for ameliorating 
      lifespan. FOXO proteins act as nuclear transcription factors that facilitate the 
      action of insulin or insulin-like growth factor (IGF-1) in various physiological 
      processes. The rationale of our study is to find out association between genetic 
      variant rs2253310 of FOXO3 and risk of Type 2 Diabetes Mellitus (T2DM) in elderly 
      population. This case control study involved 172 age sex matched elderly subjects 
      while patients were recruited as per IDF criteria. Clinical, biochemical, ELISA 
      methods were employed for assesement of clinical samples while Taqman method was 
      used for genotyping analysis. Our results revealed that there was no significant 
      difference in genotypic and allelic frequencies for the tested SNP (p > 0.05) 
      between elderly T2DM patients and controls. The SNP rs2253310 was not associated 
      with risk of T2DM in any genetic model. Also no association was found among the 
      studied group between FOXO3 variant and HOMA-IR, HOMA-B index and Fasting plasma 
      glucose. Serum level of inflammatory markers like CRP and TNF-alpha was significantly 
      higher in patients but its not associated with SNP rs2253310. Our study concluded 
      that, this intronic longevity-associated variant rs2253310 in FOXO3 is not 
      associated with type 2 diabetes in geriatric patients of northern India.
CI  - (c) Association of Clinical Biochemists of India 2020.
FAU - Hussain, Sartaj
AU  - Hussain S
AD  - Department of Pharmacology and Therapeutics, King George's Medical University, 
      Lucknow, 226003 India. GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
FAU - Dwivedi, Kanak Lata
AU  - Dwivedi KL
AD  - Department of Pharmacology and Therapeutics, King George's Medical University, 
      Lucknow, 226003 India. GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
FAU - Yadav, Suraj Singh
AU  - Yadav SS
AD  - Department of Pharmacology and Therapeutics, King George's Medical University, 
      Lucknow, 226003 India. GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
FAU - Usman, Kauser
AU  - Usman K
AD  - Department of Medicine, King George's Medical University, Lucknow, 226003 India. 
      GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
FAU - Nath, Rajendra
AU  - Nath R
AD  - Department of Pharmacology and Therapeutics, King George's Medical University, 
      Lucknow, 226003 India. GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
FAU - Khattri, Sanjay
AU  - Khattri S
AD  - Department of Pharmacology and Therapeutics, King George's Medical University, 
      Lucknow, 226003 India. GRID: grid.411275.4. ISNI: 0000 0004 0645 6578
LA  - eng
PT  - Journal Article
DEP - 20200810
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC8215020
OTO - NOTNLM
OT  - FOXO3
OT  - Geriatric
OT  - Type 2 Diabetes Mellitus
OT  - rs2253310
COIS- Conflict of interestAll authors declare that they have no conflict of interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/07/06 06:01
PMCR- 2022/07/01
CRDT- 2021/07/05 09:54
PHST- 2020/04/05 00:00 [received]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2021/07/05 09:54 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/07/06 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 917 [pii]
AID - 10.1007/s12291-020-00917-2 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2021 Jul;36(3):330-336. doi: 10.1007/s12291-020-00917-2. 
      Epub 2020 Aug 10.