PMID- 34220433
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210706
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Altered Functional Connectivity of Insular Subregions in Type 2 Diabetes 
      Mellitus.
PG  - 676624
LID - 10.3389/fnins.2021.676624 [doi]
LID - 676624
AB  - Diabetes-related brain damage can lead to cognitive decline and increase the risk 
      of depression, but the neuropathological mechanism of this phenomenon remains 
      unclear. Different insular subregions have obvious functional heterogeneity, 
      which is related to many aspects of type 2 diabetes mellitus (T2DM)-related brain 
      damage. However, little is known about changes in functional connectivity (FC) in 
      insular subregions in patients with T2DM. Therefore, we aimed to investigate FC 
      between different insular subregions and clinical/cognitive variables in patients 
      with T2DM. Fifty-seven patients with T2DM and 55 healthy controls (HCs) underwent 
      a neuropsychological assessment and resting-state FC examination. We defined 
      three insular subregions, including the bilateral dorsal anterior insula (dAI), 
      bilateral ventral anterior insula (vAI), and bilateral posterior insula (PI). We 
      examined differences in FC between insular subregions and the whole brain in 
      patients with T2DM compared with HCs. A correlation analysis was performed to 
      examine the relationship between FC and clinical/cognitive variables. Compared 
      with HCs, patients with T2DM showed significantly decreased FC between the dAI 
      and the right inferior frontal gyrus, right superior/middle temporal gyrus, right 
      hippocampus, and right precentral gyrus. FC between the vAI and the right 
      supramarginal gyrus, as well as the PI and the right precentral/postcentral 
      gyrus, was reduced in the T2DM group compared with the control group. In the T2DM 
      group, we showed a significant negative correlation between glycated hemoglobin 
      concentration and FC in the dAI and right hippocampus (r = -0.428, P = 0.001) 
      after Bonferroni correction. We conclude that different insular subregions 
      present distinct FC patterns with functional regions and that abnormal FC in 
      these insular subregions may affect cognitive, emotional, and sensorimotor 
      functions in patients with T2DM.
CI  - Copyright (c) 2021 Zhang, Wang, Gao, Huang, Qi, Lei, Ai, Yan, Cheng, Su, Lei and 
      Zhang.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Wang, Man
AU  - Wang M
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Huang, Yang
AU  - Huang Y
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Qi, Fei
AU  - Qi F
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Lei, Yumeng
AU  - Lei Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical Science, Philips Healthcare, Xi'an, China.
FAU - Yan, Xuejiao
AU  - Yan X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Cheng, Miao
AU  - Cheng M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Su, Yu
AU  - Su Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Lei, Xiaoyan
AU  - Lei X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20210616
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8242202
OTO - NOTNLM
OT  - functional connectivity
OT  - insula
OT  - neuroimaging
OT  - resting-state functional magnetic resonance imaging
OT  - subregion
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/07/06 06:01
PMCR- 2021/01/01
CRDT- 2021/07/05 09:58
PHST- 2021/03/05 00:00 [received]
PHST- 2021/05/06 00:00 [accepted]
PHST- 2021/07/05 09:58 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/07/06 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.676624 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Jun 16;15:676624. doi: 10.3389/fnins.2021.676624. 
      eCollection 2021.