PMID- 34220486
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210706
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A 
      Meta-Analysis of Resting-State Functional MRI Studies.
PG  - 678359
LID - 10.3389/fnagi.2021.678359 [doi]
LID - 678359
AB  - Objective: Resting-state functional magnetic resonance imaging (rs-fMRI) studies 
      have revealed inconsistent regional spontaneous neural activity alterations in 
      patients with type 2 diabetes mellitus (T2DM). The aim of our meta-analysis was 
      to identify concordant regional spontaneous neural activity abnormalities in 
      patients with T2DM. Methods: A systematic search was conducted to identify 
      voxel-based rs-fMRI studies comparing T2DM patients with healthy controls. The 
      permutation of subject images seed-based d mapping (SDM) was used to 
      quantitatively estimate the regional spontaneous neural activity abnormalities in 
      patients with T2DM. Metaregression was conducted to examine the associations 
      between clinical characteristics and functional alterations. Results: A total of 
      16 studies with 19 datasets including 434 patients with T2DM and 391 healthy 
      controls were included. Patients with T2DM showed hypoactivity in the right 
      medial superior frontal gyrus, right superior temporal gyrus, and left lingual 
      gyrus, whereas hyperactivity in the right cerebellum. Metaregression analysis 
      identified negative correlation between regional activity in the medial superior 
      frontal and anterior cingulate gyri and illness duration of patients with T2DM. 
      Conclusion: The patterns of regional spontaneous neural activity alterations, 
      characterized by hypoactivity in the medial pre-frontal cortex, visual cortex, 
      and superior temporal gyrus, whereas hyperactivity in the cerebellum, might 
      represent the underlying neuropathological mechanisms of T2DM.
CI  - Copyright (c) 2021 Liu, Li, Yang, Xu, Ren and Zhou.
FAU - Liu, Jieke
AU  - Liu J
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Li, Yong
AU  - Li Y
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Yang, Xi
AU  - Yang X
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Xu, Hao
AU  - Xu H
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Ren, Jing
AU  - Ren J
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
FAU - Zhou, Peng
AU  - Zhou P
AD  - Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer 
      Center, School of Medicine, University of Electronic Science and Technology of 
      China, Chengdu, China.
LA  - eng
PT  - Systematic Review
DEP - 20210617
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8245688
OTO - NOTNLM
OT  - meta-analysis
OT  - resting-state functional magnetic resonance imaging
OT  - seed-based d mapping
OT  - spontaneous neural activity
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/07/06 06:01
PMCR- 2021/01/01
CRDT- 2021/07/05 09:59
PHST- 2021/03/09 00:00 [received]
PHST- 2021/05/11 00:00 [accepted]
PHST- 2021/07/05 09:59 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/07/06 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.678359 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Jun 17;13:678359. doi: 10.3389/fnagi.2021.678359. 
      eCollection 2021.