PMID- 34220798
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 12
DP  - 2021
TI  - Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe 
      Aplastic Anemia.
PG  - 631954
LID - 10.3389/fimmu.2021.631954 [doi]
LID - 631954
AB  - Severe aplastic anemia (SAA) is a life-threatening form of bone marrow failure 
      that is associated with very high mortality. Dendritic cells (DCs) are antigen 
      presenting cells (APCs) with powerful movement ability, which is an important 
      factor affecting immune function. The expression of profilin1 (Pfn1) plays an 
      important role in the regulation of cell movement ability. We detected the 
      expression of Pfn1 mRNA in the bone marrow (BM) myeloid dendritic cells (mDCs) 
      from patients with SAA using RT-PCR. Next, we examined Pfn1 expression on mDCs 
      using flow cytometry (FCM). We also assessed the relationship between Pfn1 
      expression and cytokine levels. Our data showed increased Pfn1 mRNA expression in 
      patients with SAA. The expression of Pfn1 in BM mDCs increased in SAA patients. 
      The expression of Pfn1 on mDCs and cytokines (TNF-alpha and IFN-gamma) were positively 
      correlated in the serum of untreated patients with SAA. Taken together, we found 
      that the expression of Pfn1 on mDCs of SAA patients increased, which may affect 
      the function of mDCs. Profilin 1 may be involved in the immunopathogenesis of 
      SAA.
CI  - Copyright (c) 2021 Yu, Zhao, Pan, Liu and Fu.
FAU - Yu, Hong
AU  - Yu H
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Pan, Xiaofeng
AU  - Pan X
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Liu, Chunyan
AU  - Liu C
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Fu, Rong
AU  - Fu R
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210616
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (PFN1 protein, human)
RN  - 0 (Profilins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia, Aplastic/immunology/*metabolism
MH  - Bone Marrow
MH  - Cytokines/blood
MH  - Dendritic Cells/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/metabolism
MH  - Profilins/genetics/*metabolism
MH  - Up-Regulation
MH  - Young Adult
PMC - PMC8242247
OTO - NOTNLM
OT  - antigen presenting cells
OT  - bone marrow failure
OT  - myeloid dendritic cells
OT  - profilin1
OT  - severe aplastic anemia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/09/18 06:00
PMCR- 2021/01/01
CRDT- 2021/07/05 10:00
PHST- 2020/11/21 00:00 [received]
PHST- 2021/05/17 00:00 [accepted]
PHST- 2021/07/05 10:00 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2021.631954 [doi]
PST - epublish
SO  - Front Immunol. 2021 Jun 16;12:631954. doi: 10.3389/fimmu.2021.631954. eCollection 
      2021.