PMID- 34223527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210707
IS  - 2689-288X (Electronic)
IS  - 2689-288X (Linking)
VI  - 1
IP  - 1
DP  - 2020
TI  - Effects of a High-Fat Diet on Tissue Mass, Bone, and Glucose Tolerance after 
      Chronic Complete Spinal Cord Transection in Male Mice.
PG  - 17-31
LID - 10.1089/neur.2020.0014 [doi]
AB  - Spinal cord injury (SCI) is associated with obesity and is a risk factor for type 
      2 diabetes mellitus (T2DM). Immobilization, muscle atrophy, obesity, and loss of 
      sympathetic innervation to the liver are believed to contribute to risks of these 
      abnormalities. Systematic study of the mechanisms underlying SCI-induced 
      metabolic disorders has been limited by a lack of animal models of insulin 
      resistance following SCI. Therefore, the effects of a high-fat diet (HFD), which 
      causes weight gain and glucose intolerance in neurologically intact mice, was 
      tested in mice that had undergone a spinal cord transection at thoracic vertebra 
      10 (T10) or a sham-transection. At 84 days after surgery, Sham-HFD and SCI-HFD 
      mice showed impaired intraperitoneal glucose tolerance when compared with Sham 
      control (Sham-Con) or SCI control (SCI-Con) mice fed a standard control chow. 
      Glucose tolerance in SCI-Con mice was comparable to that of Sham-Con mice. The 
      mass of paralyzed skeletal muscle, liver, and epididymal, inguinal, and omental 
      fat deposits were lower in SCI versus Sham groups, with lower liver mass present 
      in SCI-HFD versus SCI-Con animals. SCI also produced sublesional bone loss, with 
      no differences between SCI-Con and SCI-HFD groups. The results suggest that 
      administration of a HFD to mice after SCI may provide a model to better 
      understand mechanisms leading to insulin resistance post-SCI, as well as an 
      approach to study pathogenesis of glucose intolerance that is independent of 
      obesity.
CI  - (c) Zachary A. Graham et al., 2020; Published by Mary Ann Liebert, Inc.
FAU - Graham, Zachary A
AU  - Graham ZA
AD  - Research Service, Birmingham VA Medical Center, Birmingham, Alabama, USA.
AD  - Department of Cell, Developmental and Integrative Biology, University of 
      Alabama-Birmingham, Birmingham, Alabama, USA.
FAU - Liu, Xin-Hua
AU  - Liu XH
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Harlow, Lauren
AU  - Harlow L
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
FAU - Pan, Jiangping
AU  - Pan J
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
FAU - Azulai, Daniella
AU  - Azulai D
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
FAU - Tawfeek, Hesham A
AU  - Tawfeek HA
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Wnek, Russell D
AU  - Wnek RD
AD  - Research Service and Brain Rehabilitation Research Center, Malcolm Randall VA 
      Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, 
      Florida, USA.
FAU - Mattingly, Alex J
AU  - Mattingly AJ
AD  - Research Service and Brain Rehabilitation Research Center, Malcolm Randall VA 
      Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, 
      Florida, USA.
FAU - Bauman, William A
AU  - Bauman WA
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Yarrow, Joshua F
AU  - Yarrow JF
AD  - Research Service and Brain Rehabilitation Research Center, Malcolm Randall VA 
      Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, 
      Florida, USA.
AD  - Division of Endocrinology, Diabetes, and Metabolism, University of Florida 
      College of Medicine, Gainesville, Florida, USA.
FAU - Cardozo, Christopher P
AU  - Cardozo CP
AD  - Center for the Medical Consequences of SCI, James J. Peters VA Medical Center, 
      Bronx, NY, USA.
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
LA  - eng
GR  - IK2 RX002781/RX/RRD VA/United States
PT  - Journal Article
DEP - 20200723
PL  - United States
TA  - Neurotrauma Rep
JT  - Neurotrauma reports
JID - 101773091
PMC - PMC8240892
MID - NIHMS1695160
OTO - NOTNLM
OT  - high-fat diet
OT  - metabolism
OT  - paralysis
OT  - spinal cord injury
OT  - type 2 diabetes
COIS- No competing financial interests exist.
EDAT- 2021/07/06 06:00
MHDA- 2021/07/06 06:01
PMCR- 2020/07/23
CRDT- 2021/07/05 10:25
PHST- 2021/07/05 10:25 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/07/06 06:01 [medline]
PHST- 2020/07/23 00:00 [pmc-release]
AID - 10.1089/neur.2020.0014 [pii]
AID - 10.1089/neur.2020.0014 [doi]
PST - epublish
SO  - Neurotrauma Rep. 2020 Jul 23;1(1):17-31. doi: 10.1089/neur.2020.0014. eCollection 
      2020.