PMID- 34224231
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20220424
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 4
DP  - 2021
TI  - Clinical features of children with atopic dermatitis according to filaggrin gene 
      variants.
PG  - 162-166
LID - 10.15586/aei.v49i4.209 [doi]
AB  - BACKGROUND: Filament aggregating protein (Filaggrin) is a skeletal cell component 
      that provides a protective function for the epidermis. Mutations of the filaggrin 
      gene (FLG) cause a loss of filaggrin protein. These mutations are seen in 50% of 
      atopic dermatitis (AD). The aim of the study was to investigate the polymorphisms 
      and mutations of the FLG in Iranian children with AD. MATERIALS AND METHODS: This 
      project was a case-controlled study with 25 children diagnosed with AD as the 
      case group and 25 healthy children as the control group. Demographic data, 
      clinical manifestations, and filaggrin single nucleotide polymorphisms (SNPs) and 
      mutations were recorded. Blood samples were collected for the immunoglobulin E 
      (IgE) assay and complete blood count tests. RESULTS: We found a significant 
      association between the presence of polymorphism (rs66831674) and patients' age, 
      and polymorphism (rs41267154) and early onset of AD. We found no significant 
      differences between the FLG polymorphisms with respect to the severity of AD, 
      ethnicity, concurrent allergic diseases, eosinophilia, and IgE serum levels. 
      CONCLUSION: Interestingly, FLG variants (rs66831674 and rs41267154) were 
      associated with age and early onset of AD. However, additional studies are 
      required to confirm these results on a large scale of Iranian population. 
      Moreover, establishing a cohort prospective study is suggested to assess the 
      progression of other atopic disorders based on FLG polymorphisms.
FAU - Arghavan, Ziaali
AU  - Arghavan Z
AD  - Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Laleh, Sharifi
AU  - Laleh S
AD  - Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Shahram, Teimourian
AU  - Shahram T
AD  - Department of Medical Genetics, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Bita, Hasani
AU  - Bita H
AD  - Department of Medical Genetics, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Anna, Isaian
AU  - Anna I
AD  - Department of Pathology, Children's Medical Center, Tehran University of Medical 
      Sciences, Tehran, Iran; isaiian@tums.ac.ir.
FAU - Mansoureh, Shariat
AU  - Mansoureh S
AD  - Department of Immunology and Allergy, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran; m_shariat@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (FLG protein, human)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Dermatitis, Atopic/epidemiology/genetics
MH  - Eczema
MH  - Filaggrin Proteins/*genetics
MH  - Humans
MH  - Immunoglobulin E
MH  - Intermediate Filament Proteins/genetics
MH  - Iran/epidemiology
MH  - Mutation
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
OTO - NOTNLM
OT  - Iran
OT  - atopic dermatitis
OT  - filaggrin
OT  - single nucleotide polymorphism
COIS- Authors of this research have no conflicts of interest.
EDAT- 2021/07/06 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/07/05 12:34
PHST- 2021/02/04 00:00 [received]
PHST- 2021/04/23 00:00 [accepted]
PHST- 2021/07/05 12:34 [entrez]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - 10.15586/aei.v49i4.209 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 Jul 1;49(4):162-166. doi: 
      10.15586/aei.v49i4.209. eCollection 2021.