PMID- 34224601
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220731
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Print)
IS  - 0196-8092 (Linking)
VI  - 54
IP  - 1
DP  - 2022 Jan
TI  - Improvement in the appearance of cellulite and skin laxity resulting from a 
      single treatment with acoustic subcision: Findings from a multicenter pivotal 
      clinical trial.
PG  - 121-128
LID - 10.1002/lsm.23448 [doi]
AB  - INTRODUCTION AND OBJECTIVES: Surface depressions and skin laxity together play a 
      role in the appearance of cellulite. Cellulite depressions can be improved 
      through disruption of the subcutaneous fibrous structures. Some currently 
      utilized approaches accomplish this through invasive techniques requiring local 
      anesthesia and potential down time. Skin laxity can exacerbate the appearance of 
      cellulite, however current invasive approaches do little to improve skin laxity. 
      The objective of this study was to evaluate a noninvasive approach to improving 
      both cellulite depressions and skin laxity through the use of rapid acoustic 
      pulses (acoustic subcision). Safety, efficacy, tolerability, and participant 
      satisfaction results were measured. METHODS: Women (n = 56) with moderate to 
      severe cellulite were treated in a single acoustic subcision treatment session 
      without anesthesia. Posttreatment adverse events (AEs) and tolerability were 
      recorded. At 12-weeks cellulite outcomes were assessed using a 6-point simplified 
      Cellulite Severity Scale (CSS), Global Aesthetic Improvement Scale (GAIS), and a 
      participant satisfaction questionnaire. Additionally, laxity improvement was 
      measured using a 4-point Laxity Score (LS) and GAIS. RESULTS: Improvement in 
      cellulite appearance measured at 12-weeks showed that participants (n = 56) had a 
      mean CSS reduction of 1.01 (a 29.5% reduction from baseline). The posttreatment 
      photograph was correctly identified by blinded independent reviewers from 
      randomized pairs of pre/posttreatment photographs for 96.4% of participants. 
      Cellulite was graded as improved, much improved or very much improved using the 
      GAIS at 90.9% of treated locations. Finally, 92.9% of participants reported 
      positive satisfaction responses. Scoring for improvement in skin laxity 
      appearance at 12-weeks showed a mean LS reduction of 0.57 (a 27.9% reduction from 
      baseline). GAIS for laxity was graded as improved, much improved or very much 
      improved in 67.3% of treated areas. No unexpected or serious AEs were noted at 
      treatment or follow-up. Overall average pain score during treatment was 2.4 (0-10 
      pain scale) and 0.3 immediately posttreatment. CONCLUSION: A single noninvasive 
      acoustic subcision session can safely provide meaningful improvement in the 
      appearance of cellulite in terms of depressions, as well as skin laxity, with 
      minimal treatment pain and no posttreatment down time. Further improvement in 
      appearance is expected with multiple treatments over time. Additional trials to 
      verify this are planned.
CI  - (c) 2021 The Authors. Genetic Epidemiology Published by Wiley Periodicals LLC.
FAU - Tanzi, Elizabeth L
AU  - Tanzi EL
AD  - Capital Laser and Skin Care, Chevy Chase, Maryland, USA.
FAU - Capelli, Christopher C
AU  - Capelli CC
AD  - Research, Soliton, Inc, Houston, Texas, USA.
FAU - Robertson, David W
AU  - Robertson DW
AUID- ORCID: 0000-0003-0149-0868
AD  - Research, Soliton, Inc, Houston, Texas, USA.
FAU - LaTowsky, Brenda
AU  - LaTowsky B
AD  - Clear Dermatology and Aesthetic Center, North Scottsdale, Arizona, USA.
FAU - Jacob, Carolyn
AU  - Jacob C
AD  - Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois, USA.
FAU - Ibrahim, Omer
AU  - Ibrahim O
AD  - Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois, USA.
FAU - Kaminer, Michael S
AU  - Kaminer MS
AD  - SkinCare Physicians of Chestnut Hill, Chestnut Hill, Massachusetts, USA.
LA  - eng
PT  - Case Reports
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210705
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
SB  - IM
MH  - Acoustics
MH  - Buttocks
MH  - *Cellulite
MH  - *Cosmetic Techniques
MH  - Female
MH  - Humans
MH  - Patient Satisfaction
MH  - Thigh
MH  - Treatment Outcome
PMC - PMC9292379
OTO - NOTNLM
OT  - acoustic subcision
OT  - cellulite
OT  - improvement in appearance
OT  - laxity
OT  - noninvasive
OT  - rapid acoustic pulse
EDAT- 2021/07/06 06:00
MHDA- 2022/01/28 06:00
PMCR- 2022/07/18
CRDT- 2021/07/05 17:18
PHST- 2021/06/14 00:00 [accepted]
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/07/05 17:18 [entrez]
PHST- 2022/07/18 00:00 [pmc-release]
AID - LSM23448 [pii]
AID - 10.1002/lsm.23448 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2022 Jan;54(1):121-128. doi: 10.1002/lsm.23448. Epub 2021 Jul 5.