PMID- 34225279
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20220208
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 67
IP  - 9
DP  - 2021 Sep 1
TI  - A Power Tracking Algorithm for Early Detection of Centrifugal Flow Pump 
      Thrombosis.
PG  - 1018-1025
LID - 10.1097/MAT.0000000000001509 [doi]
AB  - Logfiles from the HeartWare HVAD System provide operational pump trend data to 
      aid in patient management. Pump thrombosis is commonly associated with increases 
      in the logfile power that may precede the clinical presentation. A Power Tracking 
      algorithm was developed to detect significant deviations in pump power that may 
      be associated with pump thrombus (PT). The Power Tracking algorithm was applied 
      retrospectively to logfiles captured in the ENDURANCE, ENDURANCE Supplemental, 
      and LATERAL clinical trials. From a combined dataset of 896 patients, available 
      logfiles with suspected PT (n = 70 events in 60 patients) and available logfiles 
      from patients without adverse events (AEs) (n = 106 patients, consisting of 27.4 
      patient-years of monitoring) were organized into two cohorts. The Power Tracking 
      algorithm detected PT cases on or before the recorded AE date with a sensitivity 
      of 85.7%, with detection occurring an average of 3.9 days before clinical 
      presentation. The algorithm averaged one false alarm for every 6.85 patient-years 
      of monitoring from logfiles without AEs. The favorable performance of the Power 
      Tracking algorithm may enable earlier detection of pump thrombosis and allow 
      early medical management versus surgical intervention.
CI  - Copyright (c) 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the ASAIO.
FAU - Slaughter, Mark S
AU  - Slaughter MS
AD  - From the Department of Cardiovascular and Thoracic Surgery, University of 
      Louisville, Louisville, Kentucky.
FAU - Schloglhofer, Thomas
AU  - Schloglhofer T
AUID- ORCID: 0000-0003-4354-4860
AD  - Department of Cardiac Surgery, Medical University of Vienna and Ludwig-Boltzmann 
      Institute for Cardiovascular Research, Vienna, Austria.
FAU - Rich, Jonathan D
AU  - Rich JD
AD  - Department of Cardiology, Northwestern Memorial Hospital, Chicago, Illinois.
FAU - Brown, Michael C
AU  - Brown MC
AUID- ORCID: 0000-0002-2763-915
AD  - Department of MCS Research, Medtronic, Minneapolis, Minnesota.
FAU - Kadrolkar, Abhijit
AU  - Kadrolkar A
AD  - Department of CRM Research, Medtronic, Minneapolis, Minnesota.
FAU - Ramos, Veronica
AU  - Ramos V
AD  - Department of MCS Research, Medtronic, Minneapolis, Minnesota.
FAU - Stadler, Robert W
AU  - Stadler RW
AD  - Department of CRM Research, Medtronic, Minneapolis, Minnesota.
FAU - Uriel, Nir
AU  - Uriel N
AUID- ORCID: 0000-0003-2301-3587
AD  - Division of Cardiology, Columbia University Irving Medical Center, New York.
FAU - Mahr, Claudius
AU  - Mahr C
AD  - Division of Cardiology, University of Washington, Seattle, Washington.
FAU - Sauer, Andrew J
AU  - Sauer AJ
AD  - Department of Cardiology, University of Kansas Health System, Kansas City, 
      Kansas.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Algorithms
MH  - Early Diagnosis
MH  - *Heart Failure
MH  - *Heart-Assist Devices/adverse effects
MH  - Humans
MH  - Retrospective Studies
MH  - *Thrombosis/diagnosis/etiology
PMC - PMC8404954
EDAT- 2021/07/06 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/08/30
CRDT- 2021/07/05 20:33
PHST- 2021/07/06 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/07/05 20:33 [entrez]
PHST- 2021/08/30 00:00 [pmc-release]
AID - 00002480-202109000-00010 [pii]
AID - 10.1097/MAT.0000000000001509 [doi]
PST - ppublish
SO  - ASAIO J. 2021 Sep 1;67(9):1018-1025. doi: 10.1097/MAT.0000000000001509.