PMID- 34225594
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 86
IP  - 6
DP  - 2021 Jun
TI  - Prenatal Stress in Maternal Hyperhomocysteinemia: Impairments in the Fetal 
      Nervous System Development and Placental Function.
PG  - 716-728
LID - 10.1134/S0006297921060092 [doi]
AB  - The article presents current views on maternal hyperhomocysteinemia (HHcy) as an 
      important factor causing prenatal stress and impaired nervous system development 
      in fetuses and newborns in early ontogenesis, as well as complications in 
      adulthood. Experimental data demonstrate that prenatal HHcy (PHHcy) affects the 
      morphological maturation of the brain and activity of its neurotransmitter 
      systems. Cognitive deficit observed in the offspring subjected to PHHcy in 
      experimental studies can presumably cause the predisposition to various 
      neurodegenerative diseases, as the role of maternal HHcy in the pathogenesis such 
      diseases has been proven in clinical studies. The review also discusses molecular 
      mechanisms of the HHcy neurotoxic action on the nervous system development in the 
      prenatal and early postnatal periods, which include oxidative stress, apoptosis 
      activation, changes in the DNA methylation patterns and microRNA levels, altered 
      expression and processing of neurotrophins, and neuroinflammation induced by an 
      increased production of pro-inflammatory cytokines. Special attention is given to 
      the maternal HHcy impact on the placenta function and its possible contribution 
      to the brain function impairments in the offspring. Published data suggest that 
      some effects of PHHcy on the developing fetal brain can be due to the 
      disturbances in the transport functions of the placenta resulting in an 
      insufficient supply of nutrients necessary for the proper formation and 
      functioning of brain structures.
FAU - Arutjunyan, Alexander V
AU  - Arutjunyan AV
AD  - Research Institute of Obstetrics, Gynecology and Reproductology named after 
      D.O.Ott, St. Petersburg, 199034, Russia. alexarutiunjan@gmail.com.
AD  - St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 
      197110, Russia.
FAU - Kerkeshko, Gleb O
AU  - Kerkeshko GO
AD  - St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 
      197110, Russia.
FAU - Milyutina, Yuliya P
AU  - Milyutina YP
AD  - Research Institute of Obstetrics, Gynecology and Reproductology named after 
      D.O.Ott, St. Petersburg, 199034, Russia.
FAU - Shcherbitskaia, Anastasiia D
AU  - Shcherbitskaia AD
AD  - Research Institute of Obstetrics, Gynecology and Reproductology named after 
      D.O.Ott, St. Petersburg, 199034, Russia.
AD  - Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy 
      of Sciences, St. Petersburg, 104223, Russia.
FAU - Zalozniaia, Irina V
AU  - Zalozniaia IV
AD  - Research Institute of Obstetrics, Gynecology and Reproductology named after 
      D.O.Ott, St. Petersburg, 199034, Russia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
SB  - IM
MH  - Animals
MH  - Brain/*physiopathology
MH  - Cognitive Dysfunction/*etiology
MH  - Female
MH  - Fetal Diseases/*etiology
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Placenta/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications
OTO - NOTNLM
OT  - angiogenesis
OT  - brain
OT  - early ontogenesis
OT  - fetus
OT  - maternal hyperhomocysteinemia
OT  - neurogenesis
OT  - newborn
OT  - placenta
OT  - prenatal hyperhomocysteinemia
EDAT- 2021/07/07 06:00
MHDA- 2021/07/16 06:00
CRDT- 2021/07/06 05:33
PHST- 2021/07/06 05:33 [entrez]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
AID - BCM86060871 [pii]
AID - 10.1134/S0006297921060092 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2021 Jun;86(6):716-728. doi: 10.1134/S0006297921060092.