PMID- 34225598
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 86
IP  - 6
DP  - 2021 Jun
TI  - Blood-Brain Barrier Breakdown in Stress and Neurodegeneration: Biochemical 
      Mechanisms and New Models for Translational Research.
PG  - 746-760
LID - 10.1134/S0006297921060122 [doi]
AB  - Blood-brain barrier (BBB) is a structural and functional element of the 
      neurovascular unit (NVU), which includes cells of neuronal, glial, and 
      endothelial nature. The main functions of NVU include maintenance of the control 
      of metabolism and chemical homeostasis in the brain tissue, ensuring adequate 
      blood flow in active regions, regulation of neuroplasticity processes, which is 
      realized through intercellular interactions under normal conditions, under 
      stress, in neurodegeneration, neuroinfection, and neurodevelopmental diseases. 
      Current versions of the BBB and NVU models, static and dynamic, have 
      significantly expanded research capabilities, but a number of issues remain 
      unresolved, in particular, personification of the models for a patient. In 
      addition, application of both static and dynamic models has an important problem 
      associated with the difficulty in reproducing pathophysiological mechanisms 
      responsible for the damage of the structural and functional integrity of the 
      barrier in the diseases of the central nervous system. More knowledge on the 
      cellular and molecular mechanisms of BBB and NVU damage in pathology is required 
      to solve this problem. This review discusses current state of the cellular and 
      molecular mechanisms that control BBB permeability, pathobiochemical mechanisms 
      and manifestations of BBB breakdown in stress and neurodegenerative diseases, as 
      well as the problems and prospects of creating in vitro BBB and NVU models for 
      translational studies in neurology and neuropharmacology. Deciphering BBB 
      (patho)physiology will open up new opportunities for further development in the 
      related areas of medicine such as regenerative medicine, neuropharmacology, and 
      neurorehabilitation.
FAU - Salmina, Alla B
AU  - Salmina AB
AD  - Division of Brain Sciences, Research Center of Neurology, Moscow, 125367, Russia. 
      allasalmina@mail.ru.
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Komleva, Yuliya K
AU  - Komleva YK
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Malinovskaya, Nataliya A
AU  - Malinovskaya NA
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Morgun, Andrey V
AU  - Morgun AV
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Teplyashina, Elena A
AU  - Teplyashina EA
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Lopatina, Olga L
AU  - Lopatina OL
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Gorina, Yana V
AU  - Gorina YV
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Kharitonova, Ekaterina V
AU  - Kharitonova EV
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Khilazheva, Elena D
AU  - Khilazheva ED
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
FAU - Shuvaev, Anton N
AU  - Shuvaev AN
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Prof. V. F. 
      Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, 
      Russia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
SB  - IM
MH  - Blood-Brain Barrier/metabolism/*physiopathology
MH  - Humans
MH  - Neurodegenerative Diseases/metabolism/*physiopathology
MH  - Stress, Psychological/metabolism/*physiopathology
OTO - NOTNLM
OT  - blood-brain barrier
OT  - brain
OT  - neurodegeneration
OT  - stress
EDAT- 2021/07/07 06:00
MHDA- 2021/07/16 06:00
CRDT- 2021/07/06 05:33
PHST- 2021/07/06 05:33 [entrez]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
AID - BCM86060917 [pii]
AID - 10.1134/S0006297921060122 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2021 Jun;86(6):746-760. doi: 10.1134/S0006297921060122.