PMID- 34225661 OWN - NLM STAT- MEDLINE DCOM- 20210721 LR - 20210721 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 21 IP - 1 DP - 2021 Jul 5 TI - Prevalence and correlates of Mycoplasma genitalium infection among patients attending a sexually transmitted infection clinic in Guangdong, China: a cross-sectional study. PG - 649 LID - 10.1186/s12879-021-06349-4 [doi] LID - 649 AB - BACKGROUND: Mycoplasma genitalium (MG) causes urogenital tract infections and is associated with reproductive morbidity. Although MG has been reported across many regions and population groups, it is not yet routinely tested for in China. Our study contributes to current research by reporting the prevalence and correlates of MG infection in patients attending a sexually transmitted infection (STI) clinic in Guangdong from Jan 2017-May 2018. METHODS: Urethral (from 489 men) and endo-cervical (from 189 women) samples, blood samples, and patient histories (via questionnaires) were collected. Doctors clinically diagnosed anogenital warts (GW) during the examination (n = 678). The presence of MG was evaluated using an in-house via polymerase chain reaction protocol. We also tested all participants for herpes simplex virus-2 (HSV-2), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), syphilis and HIV. Univariate and multivariate logistic regression were used to evaluate factors associated with MG. RESULTS: MG was detected in 7.2% (49/678) of the patients (men, 7.4%; women, 6.9%). The MG positivity rate was 14.2% among symptomatic patients, and 5.6% for asymptomatic patients, respectively. Only 36.7% (18/49) Mg positive patients were symptomatic. Among the MG-infected patients, 10.2% were co-infected with CT, 6.1% with NG, 8.2% with HSV-2, 4.1% with syphilis and 22.4% with GW. Presentation with clinical symptoms was significantly associated with MG infection [OR = 2.52 (2.03-3.13)]. In our analysis, MG was not associated with other STIs. CONCLUSIONS: MG is a relatively common infection among individuals attending an STI clinic in Guangdong Province. Routine testing of symptomatic patients may be necessary, and more epidemiological studies are needed to provide evidence for future testing guidelines. FAU - Zhang, Xiao-Hui AU - Zhang XH AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Zhao, Pei-Zhen AU - Zhao PZ AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Ke, Wu-Jian AU - Ke WJ AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Wang, Liu-Yuan AU - Wang LY AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Tso, Lai Sze AU - Tso LS AD - Department of Culture Studies and Oriental Languages, University of Oslo, Oslo, Norway. AD - Anthropology, Massachusetts Institute of Technology, Cambridge, MA, USA. AD - Center for Health and Human Development Studies, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Chen, Zheng-Yu AU - Chen ZY AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Liao, Yu-Ying AU - Liao YY AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Liang, Chun-Mei AU - Liang CM AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Chen, Hui-Ru AU - Chen HR AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Ren, Xu-Qi AU - Ren XQ AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Huang, Jin-Mei AU - Huang JM AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. FAU - Ong, Jason J AU - Ong JJ AD - Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK. AD - Central Clinical School, Monash University, Melbourne, Australia. FAU - Yang, Fan AU - Yang F AD - University of North Carolina, UNC Project-China, Guangzhou, China. FAU - Yang, Li-Gang AU - Yang LG AUID- ORCID: 0000-0002-6775-8970 AD - Dermatology Hospital, Southern Medical University, Guangdong Province, Guangzhou, China. yanglg3@hotmail.com. AD - Guangdong Provincial Dermatology Hospital, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China. yanglg3@hotmail.com. LA - eng GR - 201704020219/Guangzhou Municipal Science and Technology Project/ PT - Journal Article DEP - 20210705 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Adolescent MH - Adult MH - China/epidemiology MH - Coinfection/*epidemiology MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Middle Aged MH - Mycoplasma Infections/*epidemiology MH - *Mycoplasma genitalium MH - Prevalence MH - Sexually Transmitted Diseases/*epidemiology PMC - PMC8256639 OTO - NOTNLM OT - Mycoplasma genitalium OT - Prevalence OT - Risk factor COIS- The authors declare that they have no competing interests. EDAT- 2021/07/07 06:00 MHDA- 2021/07/22 06:00 PMCR- 2021/07/05 CRDT- 2021/07/06 05:35 PHST- 2020/01/26 00:00 [received] PHST- 2021/06/23 00:00 [accepted] PHST- 2021/07/06 05:35 [entrez] PHST- 2021/07/07 06:00 [pubmed] PHST- 2021/07/22 06:00 [medline] PHST- 2021/07/05 00:00 [pmc-release] AID - 10.1186/s12879-021-06349-4 [pii] AID - 6349 [pii] AID - 10.1186/s12879-021-06349-4 [doi] PST - epublish SO - BMC Infect Dis. 2021 Jul 5;21(1):649. doi: 10.1186/s12879-021-06349-4.