PMID- 34226715 OWN - NLM STAT- MEDLINE DCOM- 20210927 LR - 20230205 IS - 1471-0048 (Electronic) IS - 1471-003X (Linking) VI - 22 IP - 8 DP - 2021 Aug TI - The default mode network in cognition: a topographical perspective. PG - 503-513 LID - 10.1038/s41583-021-00474-4 [doi] AB - The default mode network (DMN) is a set of widely distributed brain regions in the parietal, temporal and frontal cortex. These regions often show reductions in activity during attention-demanding tasks but increase their activity across multiple forms of complex cognition, many of which are linked to memory or abstract thought. Within the cortex, the DMN has been shown to be located in regions furthest away from those contributing to sensory and motor systems. Here, we consider how our knowledge of the topographic characteristics of the DMN can be leveraged to better understand how this network contributes to cognition and behaviour. CI - (c) 2021. Springer Nature Limited. FAU - Smallwood, Jonathan AU - Smallwood J AUID- ORCID: 0000-0002-7298-2459 AD - Department of Psychology, Queens University, Kingston, Ontario, Canada. js378@queensu.ca. FAU - Bernhardt, Boris C AU - Bernhardt BC AD - McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada. FAU - Leech, Robert AU - Leech R AUID- ORCID: 0000-0002-5801-6318 AD - Centre for Neuroimaging Science, Kings College London, London, UK. FAU - Bzdok, Danilo AU - Bzdok D AD - McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada. AD - Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada. AD - Montreal Neurological Institute (MNI) and Hospital, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. AD - Mila - Quebec Artificial Intelligence Institute, Montreal, Quebec, Canada. FAU - Jefferies, Elizabeth AU - Jefferies E AD - Department of Psychology, University of York, York, UK. FAU - Margulies, Daniel S AU - Margulies DS AUID- ORCID: 0000-0002-8880-9204 AD - Integrative Neuroscience and Cognition Center (UMR 8002), Centre National de la Recherche Scientifique (CNRS) and Universite de Paris, Paris, France. AD - Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. LA - eng GR - R01 AG068563/AG/NIA NIH HHS/United States GR - WT 203148/Z/16/WT_/Wellcome Trust/United Kingdom GR - FDN-154298/CIHR/Canada GR - PJT-174995/CIHR/Canada PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20210705 PL - England TA - Nat Rev Neurosci JT - Nature reviews. Neuroscience JID - 100962781 SB - IM MH - Brain/diagnostic imaging/*physiology MH - Brain Mapping MH - Cognition/*physiology MH - Default Mode Network/diagnostic imaging/*physiology MH - Humans MH - Magnetic Resonance Imaging EDAT- 2021/07/07 06:00 MHDA- 2021/09/28 06:00 CRDT- 2021/07/06 06:32 PHST- 2021/05/20 00:00 [accepted] PHST- 2021/07/07 06:00 [pubmed] PHST- 2021/09/28 06:00 [medline] PHST- 2021/07/06 06:32 [entrez] AID - 10.1038/s41583-021-00474-4 [pii] AID - 10.1038/s41583-021-00474-4 [doi] PST - ppublish SO - Nat Rev Neurosci. 2021 Aug;22(8):503-513. doi: 10.1038/s41583-021-00474-4. Epub 2021 Jul 5.