PMID- 34227009 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20210818 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 28 IP - 33 DP - 2021 Sep TI - Polybrominated diphenyl ethers in the environment: a wake-up call for concerted action in India. PG - 44693-44715 LID - 10.1007/s11356-021-15204-7 [doi] AB - Polybrominated diphenyl ethers (PBDEs) are a class of persistent organic pollutants (POPs) used as flame retardants in the products utilized in day-to-day life. Their bioaccumulation, low volatility, and high persistence in the environment have led to their global spread even to remote and distant regions. The present study identifies gaps in the investigation of the neurotoxic potential of PBDEs, their effects on brain development, toxicokinetic, and their potential as a carcinogen. In India, to date, only human breast milk was assessed for levels of PBDEs, and it is suggested that other human tissues can also be explored. No data on the reproductive toxicity of PBDEs are reported from Indian cohorts. Long-range transport and deposition of PBDEs in colder regions necessitates monitoring of Himalayan regions in India. An inventory of PBDEs is required to be made for addressing the worrisome situation of the unregulated import of E-waste from the developed countries in India. The study also emphasizes providing guidelines for the articulation of policies regarding sound surveillance and management of PBDE production, consumption, and release in the Indian context. It is recommended that a separate cell for monitoring and follow-up of PBDEs should be established in India. Also, the development of better alternatives and environment-friendly remediation technologies for PBDEs is the need of the hour. CI - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Paliya, Sonam AU - Paliya S AD - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. AD - CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440 020, India. FAU - Mandpe, Ashootosh AU - Mandpe A AD - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. AD - CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440 020, India. FAU - Bombaywala, Sakina AU - Bombaywala S AD - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. AD - CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440 020, India. FAU - Kumar, Manukonda Suresh AU - Kumar MS AD - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. AD - CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440 020, India. FAU - Kumar, Sunil AU - Kumar S AD - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201 002, India. s_kumar@neeri.res.in. AD - CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, 440 020, India. s_kumar@neeri.res.in. FAU - Morya, Vivek Kumar AU - Morya VK AD - Adhita Biosciences Pvt. Ltd, SIIC Extension, IIT Kanpur, Kanpur, 208 016, India. LA - eng PT - Journal Article PT - Review DEP - 20210705 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Flame Retardants) RN - 0 (Halogenated Diphenyl Ethers) SB - IM MH - Environmental Monitoring MH - Female MH - *Flame Retardants/analysis MH - *Halogenated Diphenyl Ethers/analysis MH - Humans MH - India OTO - NOTNLM OT - Accumulation OT - E-waste OT - Long-range transport OT - Policy OT - Polybrominated diphenyl ethers OT - Toxicity EDAT- 2021/07/07 06:00 MHDA- 2021/08/19 06:00 CRDT- 2021/07/06 06:42 PHST- 2020/08/27 00:00 [received] PHST- 2021/06/25 00:00 [accepted] PHST- 2021/07/07 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2021/07/06 06:42 [entrez] AID - 10.1007/s11356-021-15204-7 [pii] AID - 10.1007/s11356-021-15204-7 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2021 Sep;28(33):44693-44715. doi: 10.1007/s11356-021-15204-7. Epub 2021 Jul 5.