PMID- 34227259
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20210922
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 8
DP  - 2021 Aug
TI  - Alterations of the intrinsic amygdala-hippocampal network in juvenile myoclonic 
      epilepsy.
PG  - e2274
LID - 10.1002/brb3.2274 [doi]
LID - e2274
AB  - INTRODUCTION: Several lines of evidence suggest that the amygdala-hippocampus is 
      involved in the epileptogenic network of juvenile myoclonic epilepsy (JME). The 
      aim of this study was to investigate the alterations in the individual nuclei of 
      the amygdala and hippocampal subfields, and the intrinsic amygdala-hippocampal 
      network of patients with JME compared to healthy controls. METHODS: This 
      retrospective study conducted at a single tertiary hospital involved 35 patients 
      with newly diagnosed JME, and 34 healthy subjects. We calculated the individual 
      structural volumes of 18 nuclei in the amygdala, and 38 hippocampal subfields 
      using three-dimensional volumetric T1-weighted imaging and FreeSurfer program. We 
      also performed an analysis of the intrinsic amygdala-hippocampal global and local 
      network based on these volumes using a graph theory and Brain Analysis using 
      Graph Theory (BRAPH) program. We investigated the differences in these volumes 
      and network measures between patients with JME and healthy controls. RESULTS: 
      There were no significant volume differences in the nuclei of the amygdala and 
      hippocampal subfields between patients with JME and healthy controls. However, we 
      found significant differences in the global network between patients with JME and 
      healthy controls. The mean clustering coefficient was significantly decreased in 
      patients with JME compared to healthy controls (0.473 vs. 0.653, p = .047). In 
      addition, specific regions in the hippocampal subfields showed significant 
      differences in the local network between the two groups. The betweenness 
      centrality of the right CA1-head, right hippocampus-amygdala-transition area, 
      left hippocampal fissure, left fimbria, and left CA3-head, was increased in 
      patients with JME compared to healthy controls. CONCLUSION: The intrinsic 
      amygdala-hippocampal global and local networks differed in patients with JME 
      compared to healthy controls, which may be related to the pathogenesis of JME, 
      and memory dysfunction in patients with JME.
CI  - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Lee, Dong Ah
AU  - Lee DA
AD  - Department of Neurology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Ko, Junghae
AU  - Ko J
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Lee, Ho-Joon
AU  - Lee HJ
AD  - Department of Radiology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Kim, Hyung Chan
AU  - Kim HC
AD  - Department of Neurology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
FAU - Park, Bong Soo
AU  - Park BS
AUID- ORCID: 0000-0001-8999-386X
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Park, Sihyung
AU  - Park S
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Kim, Il Hwan
AU  - Kim IH
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Park, Jin Han
AU  - Park JH
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Lee, Yoo Jin
AU  - Lee YJ
AD  - Department of Internal Medicine, Haeundae Paik Hospital, Inje University College 
      of Medicine, Busan, Republic of Korea.
FAU - Park, Kang Min
AU  - Park KM
AUID- ORCID: 0000-0002-4229-7741
AD  - Department of Neurology, Haeundae Paik Hospital, Inje University College of 
      Medicine, Busan, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210705
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Amygdala/diagnostic imaging
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Myoclonic Epilepsy, Juvenile/diagnostic imaging
MH  - Retrospective Studies
PMC - PMC8413739
OTO - NOTNLM
OT  - amygdala
OT  - hippocampus
OT  - juvenile myoclonic epilepsy
COIS- All the authors have no conflict of interest to declare.
EDAT- 2021/07/07 06:00
MHDA- 2021/09/23 06:00
PMCR- 2021/07/05
CRDT- 2021/07/06 07:00
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/01/10 00:00 [received]
PHST- 2021/06/18 00:00 [accepted]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/07/06 07:00 [entrez]
PHST- 2021/07/05 00:00 [pmc-release]
AID - BRB32274 [pii]
AID - 10.1002/brb3.2274 [doi]
PST - ppublish
SO  - Brain Behav. 2021 Aug;11(8):e2274. doi: 10.1002/brb3.2274. Epub 2021 Jul 5.