PMID- 34227868
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 19
IP  - 8
DP  - 2021 Oct
TI  - Elevated Plasma Homocysteine Level Associated with Further Left Ventricular 
      Structure and Function Damages in Type 2 Diabetic Patients: A Three-Dimensional 
      Speckle Tracking Echocardiography Study.
PG  - 443-451
LID - 10.1089/met.2020.0142 [doi]
AB  - Aims: The aims of this study were to explore the left ventricular (LV) structural 
      remodeling and its risk factors in type 2 diabetes mellitus (T2DM) patients with 
      or without hyperhomocysteinemia (hHcy) and to detect the accompanied LV 
      dysfunction using three-dimensional speckle tracking echocardiography (3DSTE). 
      Methods: There were totally 80 T2DM patients with undamaged LV ejection fraction 
      (>/=55%) in this study, 40 of whom were also diagnosed with hHcy as co-morbidity. 
      Forty age- and gender-matched controls were also recruited. The risk factors and 
      corresponding diagnostic values for LV remodeling (LVR) were, respectively, 
      determined using logistic regression and area under the receiver operating 
      characteristic curves (AUC). The 3DSTE was used to measure global longitudinal 
      strain (GLS), global circumferential strain (GCS), global area strain (GAS), and 
      global radial strain (GRS). Results: The constituent ratio of LV geometry showed 
      significant differences among the study populations (P = 0.01). Compared with the 
      controls, three types of LVR accounted for larger proportion in the two T2DM 
      groups, whereas LV hypertrophy was most prevalent in those with T2DM and hHcy. 
      Glycosylated hemoglobin (HbA1c), total plasma homocysteine (tHcy), and HbA1c plus 
      tHcy were all significant risk factors associated with LVR in T2DM patients (AUC 
      values: 0.741, 0.746 and 0.851, respectively). The patients with T2DM alone had 
      significantly lower GLS and GAS than the controls (both P < 0.05). The patients 
      with T2DM and hHcy had significantly lower GLS, GCS, GAS, and GRS than the 
      controls (all P < 0.001), and also had significantly lower GLS, GCS, and GRS than 
      the patients with T2DM alone (all P < 0.05). Conclusions: The 3DSTE plus 
      conventional echocardiography could be used as an effective supplement for 
      detecting early and occult cardiac damages in T2DM patients with plasma 
      homocysteine at normal or elevated levels.
FAU - Wang, Qingqing
AU  - Wang Q
AUID- ORCID: 0000-0002-6950-0631
AD  - Department of Ultrasound, Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Fu, Chixue
AU  - Fu C
AD  - Department of Ultrasound, the Armed Police Corps Hospital of Chongqing, 
      Chongqing, China.
FAU - Xia, Hongmei
AU  - Xia H
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
FAU - Gao, Yunhua
AU  - Gao Y
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20210705
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/blood/complications
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Ventricles/diagnostic imaging
MH  - Homocysteine/*blood
MH  - Humans
MH  - *Hyperhomocysteinemia/blood/complications
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - Ventricular Dysfunction, Left/blood/*diagnostic imaging/etiology
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - LV function
OT  - LV remodeling (LVR)
OT  - hyperhomocysteinemia (hHcy)
OT  - risk factors
OT  - three-dimensional speckle tracking echocardiography (3DSTE)
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2021/07/07 06:00
MHDA- 2022/01/11 06:00
CRDT- 2021/07/06 12:21
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2021/07/06 12:21 [entrez]
AID - 10.1089/met.2020.0142 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2021 Oct;19(8):443-451. doi: 10.1089/met.2020.0142. 
      Epub 2021 Jul 5.