PMID- 34227910
OWN - NLM
STAT- MEDLINE
DCOM- 20220324
LR  - 20220716
IS  - 2168-8370 (Electronic)
IS  - 2168-8362 (Print)
IS  - 2168-8362 (Linking)
VI  - 9
IP  - 4
DP  - 2021 Oct 2
TI  - Connexins in the development and physiology of stem cells.
PG  - 1949242
LID - 10.1080/21688370.2021.1949242 [doi]
LID - 1949242
AB  - Connexins (Cxs) form gap junction (GJ) channels linking vertebrate cells. During 
      embryogenesis, Cxs are expressed as early as the 4-8 cell stage. As cells 
      differentiate into pluripotent stem cells (PSCs) and during gastrulation, the Cx 
      expression pattern is adapted. Knockdown of Cx43 and Cx45 does not interfere with 
      embryogenic development until the blastula stage, questioning the role of Cxs in 
      PSC physiology and development. Studies in cultivated and induced PSCs (iPSCs) 
      showed that Cx43 is essential for the maintenance of self-renewal and the 
      expression of pluripotency markers. It was found that the role of Cxs in PSCs is 
      more related to regulation of transcription or cell-cell adherence than to 
      formation of GJ channels. Furthermore, a crucial role of Cxs for the self-renewal 
      and differentiation was shown in cultivated adult mesenchymal stem cells. This 
      review aims to highlight aspects that link Cxs to the function and physiology of 
      stem cell development.
FAU - Ngezahayo, Anaclet
AU  - Ngezahayo A
AUID- ORCID: 0000-0002-3686-923X
AD  - Dept. Cell Physiology and Biophysics, Institute of Cell Biology and Biophysics, 
      Leibniz University Hannover, Hannover, Germany.
AD  - Center for Systems Neuroscience (ZSN), University of Veterinary Medicine 
      Hannover, Hannover, Germany.
FAU - Ruhe, Frederike A
AU  - Ruhe FA
AD  - Dept. Cell Physiology and Biophysics, Institute of Cell Biology and Biophysics, 
      Leibniz University Hannover, Hannover, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210706
PL  - United States
TA  - Tissue Barriers
JT  - Tissue barriers
JID - 101601065
RN  - 0 (Connexins)
SB  - IM
MH  - Cell Differentiation
MH  - *Connexins/metabolism
MH  - *Gap Junctions/metabolism
MH  - Stem Cells/metabolism
PMC - PMC8794508
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/07/07 06:00
MHDA- 2022/03/25 06:00
PMCR- 2022/07/06
CRDT- 2021/07/06 12:23
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2022/03/25 06:00 [medline]
PHST- 2021/07/06 12:23 [entrez]
PHST- 2022/07/06 00:00 [pmc-release]
AID - 1949242 [pii]
AID - 10.1080/21688370.2021.1949242 [doi]
PST - ppublish
SO  - Tissue Barriers. 2021 Oct 2;9(4):1949242. doi: 10.1080/21688370.2021.1949242. 
      Epub 2021 Jul 6.