PMID- 34228273
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20220118
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 48
IP  - 6
DP  - 2021 Jun
TI  - Inflammatory, antioxidant and glycemic status to different mode of high-intensity 
      training in type 2 diabetes mellitus.
PG  - 5291-5304
LID - 10.1007/s11033-021-06539-y [doi]
AB  - BACKGROUND: Exercise has traditionally been used and prescribed as an effective 
      and suitable way to treat type 2 diabetics Mellitus (T2DM). In this regard, we 
      compared inflammatory, antioxidant, and glycemic status to different kinds of 
      high-intensity interval training (strength training, HIIT, and HIIT + ST) in 
      patients with T2DM. METHODS AND RESULTS: Fifty-nine T2DM patients (age = 45-60 
      yrs) were randomly divided to strength training (ST) (n = 15), high intensity 
      interval training (HIIT) (n = 16), HIIT + ST (n = 15) or served as control (CON) 
      (n = 13) groups. Experimental groups performed three training sessions/week for 
      12 weeks. Inflammatory, antioxidant, glycemic factors, and anthropometric 
      parameters were evaluated at baseline and after the 12 weeks of interventions. 
      Training HIIT groups significantly improved antioxidant factors, lipid profile, 
      and glycemic parameters (P </= 0.05). Interleukin 6 (IL-6), C-reactive protein 
      (CRP), and tumor necrosis factor-alpha (TNF-alpha) significantly decreased in the three 
      training groups. As a result of training, the overall inflammatory and 
      antioxidant status were improved considerably in all three training groups 
      compared to the CON group (P </= 0.05). In addition, there were significant 
      differences in CRP at the follow-up values between ST and CON groups (P </= 0.05). 
      Exercise time and TC were significantly improved in HIIT than in the CON group 
      (P </= 0.05). The results showed a significant difference between the HIIT + ST 
      group and the CON group in VO2(peak) (P </= 0.05). CONCLUSIONS: Our results showed 
      improvement in inflammatory factors, antioxidants, and glycemic parameters in all 
      training groups regardless of their type. However, for more benefits in T2DM 
      patients, combination exercises can be suggested.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Sabouri, Mostafa
AU  - Sabouri M
AUID- ORCID: 0000-0001-5088-7955
AD  - Department of Exercise Physiology & Health Science, University of Tehran, Tehran, 
      Iran. Mostafasaboory@ut.ac.ir.
FAU - Hatami, Elaheh
AU  - Hatami E
AD  - Department of Exercise Physiology, Sport Sciences Research Institute, Tehran, 
      Iran.
FAU - Pournemati, Parisa
AU  - Pournemati P
AD  - Department of Exercise Physiology & Health Science, University of Tehran, Tehran, 
      Iran.
FAU - Shabkhiz, Fatemeh
AU  - Shabkhiz F
AD  - Department of Exercise Physiology & Health Science, University of Tehran, Tehran, 
      Iran. shabkhiz@ut.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20210706
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Antioxidants/physiology
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Diabetes Mellitus, Type 2/*therapy
MH  - Exercise/physiology
MH  - Female
MH  - Glucose/*metabolism
MH  - High-Intensity Interval Training/*methods
MH  - Humans
MH  - Inflammation/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Middle Aged
MH  - Resistance Training/methods
OTO - NOTNLM
OT  - HIIT
OT  - Inflammatory markers
OT  - Oxidative stress
OT  - T2DM
EDAT- 2021/07/07 06:00
MHDA- 2022/01/19 06:00
CRDT- 2021/07/06 13:24
PHST- 2021/02/10 00:00 [received]
PHST- 2021/06/27 00:00 [accepted]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
PHST- 2021/07/06 13:24 [entrez]
AID - 10.1007/s11033-021-06539-y [pii]
AID - 10.1007/s11033-021-06539-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2021 Jun;48(6):5291-5304. doi: 10.1007/s11033-021-06539-y. Epub 
      2021 Jul 6.