PMID- 34228338
OWN - NLM
STAT- MEDLINE
DCOM- 20221014
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 29
IP  - 5
DP  - 2022 Oct
TI  - Localization of myocardial FDG uptake for prognostic risk stratification in 
      corticosteroid-naive cardiac sarcoidosis.
PG  - 2132-2144
LID - 10.1007/s12350-021-02684-w [doi]
AB  - BACKGROUND: The localization of myocardial 18F-fluorodeoxyglucose (FDG) uptake 
      affecting long-term clinical outcomes has not been elucidated in patients with 
      corticosteroid-naive cardiac sarcoidosis (CS). OBJECTIVES: This study sought to 
      investigate the localization of myocardial FDG uptake on positron emission 
      tomography (PET) and myocardial perfusion abnormality to predict adverse events 
      (AEs) for a long-term follow-up in patients with corticosteroid-naive CS. 
      METHODS: Consecutive 90 patients with clinical suspicion of CS who underwent 
      FDG-PET imaging to assess for inflammation were enrolled. AEs were defined as a 
      composite of sustained ventricular tachycardia (VT), heart transplantation, and 
      all-cause death, which were ascertained by medical records, defibrillator 
      interrogation, and telephone interviews. RESULTS: Of 90 patients, 42 patients 
      (mean age 62.9 +/- 12.0 years; 76.2% females) were confirmed active cardiac 
      involvement. Over a median follow-up of 4.9 years, 15 patients with CS 
      experienced AEs including 6 sustained ventricular tachycardias (VT) and 9 deaths. 
      Cox proportional-hazards model after adjustment for left ventricular systolic 
      dysfunction revealed that FDG uptake in the right ventricle (RV) or basal 
      anterolateral area of the left ventricle (LV) with myocardial perfusion 
      abnormality was predictive of AEs. CONCLUSIONS: FDG uptake in the RV or basal 
      anterolateral area of the LV with myocardial perfusion abnormality provides 
      long-term prognostic risk stratification in patients with corticosteroid-naive 
      CS.
CI  - (c) 2021. American Society of Nuclear Cardiology.
FAU - Bekki, Munehisa
AU  - Bekki M
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Tahara, Nobuhiro
AU  - Tahara N
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. 
      ntahara@med.kurume-u.ac.jp.
FAU - Tahara, Atsuko
AU  - Tahara A
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Sugiyama, Yoichi
AU  - Sugiyama Y
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Maeda-Ogata, Shoko
AU  - Maeda-Ogata S
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Honda, Akihiro
AU  - Honda A
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Igata, Sachiyo
AU  - Igata S
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Enomoto, Mika
AU  - Enomoto M
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
FAU - Kakuma, Tatsuyuki
AU  - Kakuma T
AD  - Biostatics Center, Kurume University, Kurume, Japan.
FAU - Kaida, Hayato
AU  - Kaida H
AD  - Department of Radiology, Faculty of Medicine, Kindai University, Osakasayama, 
      Osaka, Japan.
FAU - Abe, Toshi
AU  - Abe T
AD  - Department of Radiology, Kurume University School of Medicine, Kurume, Japan.
FAU - Fukumoto, Yoshihiro
AU  - Fukumoto Y
AD  - Division of Cardiovascular Medicine, Department of Medicine, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210706
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
EIN - J Nucl Cardiol. 2021 Oct;28(5):2361. doi: 10.1007/s12350-021-02740-5. PMID: 
      34327670
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Aged
MH  - *Cardiomyopathies/complications
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocarditis/complications
MH  - Positron-Emission Tomography
MH  - Prognosis
MH  - Radiopharmaceuticals
MH  - Risk Assessment
MH  - *Sarcoidosis/complications
MH  - *Tachycardia, Ventricular/etiology
MH  - Tomography, X-Ray Computed/adverse effects
OTO - NOTNLM
OT  - Cardiac sarcoidosis
OT  - FDG-PET
OT  - adverse events
OT  - myocardial inflammation
EDAT- 2021/07/07 06:00
MHDA- 2022/10/15 06:00
CRDT- 2021/07/06 13:25
PHST- 2020/06/05 00:00 [received]
PHST- 2021/05/12 00:00 [accepted]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2022/10/15 06:00 [medline]
PHST- 2021/07/06 13:25 [entrez]
AID - S1071-3581(23)00531-7 [pii]
AID - 10.1007/s12350-021-02684-w [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2022 Oct;29(5):2132-2144. doi: 10.1007/s12350-021-02684-w. Epub 
      2021 Jul 6.