PMID- 34228878
OWN - NLM
STAT- MEDLINE
DCOM- 20220922
LR  - 20221025
IS  - 1742-4658 (Electronic)
IS  - 1742-464X (Linking)
VI  - 289
IP  - 18
DP  - 2022 Sep
TI  - Regulation of redox signaling in HIF-1-dependent tumor angiogenesis.
PG  - 5413-5425
LID - 10.1111/febs.16110 [doi]
AB  - Angiogenesis is the process of blood vessel growth. The angiogenic switch 
      consists of new blood vessel formation that, in carcinogenesis, can lead to the 
      transition from a harmless cluster of dormant cells to a large tumorigenic mass 
      with metastatic potential. Hypoxia, that is, the scarcity of oxygen, is a 
      hallmark of solid tumors to which they adapt by activating hypoxia-inducible 
      factor-1 (HIF-1), a transcription factor triggering de novo angiogenesis. HIF-1 
      and the angiogenic molecules that are expressed upon its activation are modulated 
      by redox status. Modulations of the redox environment can influence the 
      angiogenesis signaling at different levels, thereby impinging on the angiogenic 
      switch. This review provides a molecular overview of the redox-sensitive steps in 
      angiogenic signaling, the main molecular players involved, and their crosstalk 
      with the unfolded protein response. New classes of inhibitors of these modulators 
      which might act as antiangiogenic drugs in cancer are also discussed.
CI  - (c) 2021 Federation of European Biochemical Societies.
FAU - Manuelli, Valeria
AU  - Manuelli V
AD  - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
FAU - Pecorari, Chiara
AU  - Pecorari C
AD  - Redox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
FAU - Filomeni, Giuseppe
AU  - Filomeni G
AD  - Redox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
AD  - Center for Healthy Aging, Copenhagen University, Denmark.
AD  - Department of Biology, Tor Vergata University, Rome, Italy.
FAU - Zito, Ester
AU  - Zito E
AUID- ORCID: 0000-0001-7786-7698
AD  - Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
AD  - Department of Biomolecular Sciences, University of Urbino Carlo Bo, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210716
PL  - England
TA  - FEBS J
JT  - The FEBS journal
JID - 101229646
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Hypoxia
MH  - *Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism
MH  - *Neoplasms/pathology
MH  - Neovascularization, Pathologic/pathology
MH  - Oxidation-Reduction
MH  - Oxygen
OTO - NOTNLM
OT  - ER stress
OT  - ERO1
OT  - HIF-1
OT  - UPR
OT  - angiogenesis
OT  - hypoxia
OT  - metastasis
EDAT- 2021/07/07 06:00
MHDA- 2022/09/23 06:00
CRDT- 2021/07/06 17:29
PHST- 2021/05/24 00:00 [revised]
PHST- 2021/03/29 00:00 [received]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2022/09/23 06:00 [medline]
PHST- 2021/07/06 17:29 [entrez]
AID - 10.1111/febs.16110 [doi]
PST - ppublish
SO  - FEBS J. 2022 Sep;289(18):5413-5425. doi: 10.1111/febs.16110. Epub 2021 Jul 16.