PMID- 34228982
OWN - NLM
STAT- MEDLINE
DCOM- 20211221
LR  - 20211221
IS  - 1873-2399 (Electronic)
IS  - 0301-472X (Linking)
VI  - 100
DP  - 2021 Aug
TI  - Human, mouse, and dog bone marrow show similar mesenchymal stromal cells within a 
      distinctive microenvironment.
PG  - 41-51
LID - S0301-472X(21)00246-0 [pii]
LID - 10.1016/j.exphem.2021.06.006 [doi]
AB  - Bone marrow stromal cells (BMSCs) are a key part of the hematopoietic niche. 
      Mouse and human BMSCs are recognized by different markers (LepR and NGFR/CD271, 
      respectively). However, there has not been a detailed in situ comparison of both 
      populations within the hematopoietic microenvironment. Moreover, dog BMSCs have 
      not been characterized in situ by any of those markers. We conducted a systematic 
      histopathological comparison of mouse, human, and dog BMSCs within their bone 
      marrow architecture and microenvironment. Human and dog CD271+ BMSCs had a 
      morphology, frequency, and distribution within trabecular bone marrow similar to 
      those of mouse LepR+ BMSCs. However, mouse bone marrow had higher cellularity and 
      megakaryocyte content. In conclusion, highly comparable bone marrow mesenchymal 
      stromal cell distribution among the three species establishes the validity of 
      using mouse and dog as a surrogate experimental model of hematopoietic stem 
      cell-BMSC interactions. However, the distinct differences in adipocyte and 
      megakaryocyte microenvironment content of mouse bone marrow and how they might 
      influence hematopoietic stem cell interactions as compared with humans require 
      further study.
CI  - Copyright (c) 2021 ISEH -- Society for Hematology and Stem Cells. Published by 
      Elsevier Inc. All rights reserved.
FAU - Meza-Leon, Berenice
AU  - Meza-Leon B
AD  - Unidad de Investigacion Medica en Enfermedades Oncologicas. Centro Medico 
      Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
FAU - Gratzinger, Dita
AU  - Gratzinger D
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA.
FAU - Aguilar-Navarro, Alicia G
AU  - Aguilar-Navarro AG
AD  - Unidad de Investigacion Medica en Enfermedades Oncologicas. Centro Medico 
      Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
FAU - Juarez-Aguilar, Fany G
AU  - Juarez-Aguilar FG
AD  - Departamento de Patologia, Hospital de Especialidades, Centro Medico Nacional 
      Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
FAU - Rebel, Vivienne I
AU  - Rebel VI
AD  - Department of Cell Systems & Anatomy, The University of Texas Health Science 
      Center at San Antonio, San Antonio, TX.
FAU - Torlakovic, Emina
AU  - Torlakovic E
AD  - Saskatchewan Health Authority (SHA), Saskatoon, Saskatchewan, Canada; University 
      of Saskatchewan, Saskatchewan, Canada.
FAU - Purton, Louise E
AU  - Purton LE
AD  - St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia; Department 
      of Medicine, University of Melbourne, Parkville, VIC, Australia.
FAU - Dorantes-Acosta, Elisa M
AU  - Dorantes-Acosta EM
AD  - Biobanco de Investigacion en Celulas Leucemicas, Hospital Infantil de Mexico 
      Federico Gomez, Mexico City, Mexico.
FAU - Escobar-Sanchez, Argelia
AU  - Escobar-Sanchez A
AD  - Departamento de Patologia, Hospital infantil de Mexico Federico Gomez, Mexico 
      City, Mexico.
FAU - Dick, John E
AU  - Dick JE
AD  - Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; 
      Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
FAU - Flores-Figueroa, Eugenia
AU  - Flores-Figueroa E
AD  - Unidad de Investigacion Medica en Enfermedades Oncologicas. Centro Medico 
      Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico; 
      Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. 
      Electronic address: eugenia.flores-figueroa@uhnresearch.ca.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210703
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (NGFR protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Leptin)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Child
MH  - Dogs
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/ultrastructure
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, SCID
MH  - Nerve Tissue Proteins/analysis
MH  - Receptors, Leptin/analysis
MH  - Receptors, Nerve Growth Factor/analysis
MH  - Species Specificity
MH  - Stem Cell Niche
EDAT- 2021/07/07 06:00
MHDA- 2021/12/22 06:00
CRDT- 2021/07/06 20:11
PHST- 2021/06/02 00:00 [received]
PHST- 2021/06/22 00:00 [revised]
PHST- 2021/06/26 00:00 [accepted]
PHST- 2021/07/07 06:00 [pubmed]
PHST- 2021/12/22 06:00 [medline]
PHST- 2021/07/06 20:11 [entrez]
AID - S0301-472X(21)00246-0 [pii]
AID - 10.1016/j.exphem.2021.06.006 [doi]
PST - ppublish
SO  - Exp Hematol. 2021 Aug;100:41-51. doi: 10.1016/j.exphem.2021.06.006. Epub 2021 Jul 
      3.