PMID- 34229382
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 417
DP  - 2021 Sep 5
TI  - Early-life chronic di(2-ethylhexyl)phthalate exposure worsens age-related 
      long-term associative memory decline associated with insulin/IGF-1 signaling and 
      CRH-1/CREB in Caenorhabditis elegans.
PG  - 126044
LID - S0304-3894(21)01008-6 [pii]
LID - 10.1016/j.jhazmat.2021.126044 [doi]
AB  - The ubiquitous contamination of di(2-ethylhexyl)phthalate (DEHP) in the 
      environment, biota, and food poses potential ecological and human health risks. 
      DEHP exposure can adversely affect learning and memory, yet the underlying 
      mechanisms remain unclear. In this study, Caenorhabditis elegans was used to 
      investigate the effect of early-life DEHP exposure on age-related long-term 
      associative memory (LTAM) decline, as well as the associations with the 
      cAMP-responsive element-binding protein (CREB) transcription factor and 
      insulin/IGF-1 signaling (IIS). We showed that early-life exposure to DEHP reduced 
      LTAM in wild-type worms at day-0 adulthood. Chronic exposure to DEHP from the L1 
      stage to day-5 adulthood worsened the age-dependent decline of LTAM. Moreover, 
      the effect of DEHP on age-related LTAM requires CRH-1, a homolog of CREB. 
      Mutations in daf-2, the sole receptor of C. elegans IIS, ameliorated the 
      inhibition of LTAM by DEHP, and the effect depended on daf-16. In addition, daf-2 
      mutation restored the CRH-1 level in DEHP-exposed worms, and the effect required 
      daf-16. Our study suggests that early-life chronic exposure to DEHP worsens 
      age-related LTAM decline and the effect is associated with CRH-1 and IIS in C. 
      elegans. The evolutionary conservation of IIS and CREB implies possible adverse 
      effects by DEHP across species.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - How, Chun Ming
AU  - How CM
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan.
FAU - Lin, Ting-An
AU  - Lin TA
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan.
FAU - Liao, Vivian Hsiu-Chuan
AU  - Liao VH
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan. Electronic address: vivianliao@ntu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210509
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (CRH-1 protein, C elegans)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Insulin)
RN  - 0 (Transcription Factors)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Caenorhabditis elegans/genetics
MH  - *Caenorhabditis elegans Proteins/genetics
MH  - *Diethylhexyl Phthalate/toxicity
MH  - Humans
MH  - Insulin
MH  - Insulin-Like Growth Factor I
MH  - Memory Disorders
MH  - Transcription Factors
OTO - NOTNLM
OT  - CRH-1/CREB
OT  - DEHP
OT  - Insulin/IGF-1 signaling
OT  - Memory decline
EDAT- 2021/07/08 06:00
MHDA- 2021/07/29 06:00
CRDT- 2021/07/07 01:02
PHST- 2021/02/06 00:00 [received]
PHST- 2021/04/27 00:00 [revised]
PHST- 2021/05/03 00:00 [accepted]
PHST- 2021/07/07 01:02 [entrez]
PHST- 2021/07/08 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
AID - S0304-3894(21)01008-6 [pii]
AID - 10.1016/j.jhazmat.2021.126044 [doi]
PST - ppublish
SO  - J Hazard Mater. 2021 Sep 5;417:126044. doi: 10.1016/j.jhazmat.2021.126044. Epub 
      2021 May 9.