PMID- 3423017
OWN - NLM
STAT- MEDLINE
DCOM- 19880202
LR  - 20200930
IS  - 0037-9727 (Print)
IS  - 0037-9727 (Linking)
VI  - 186
IP  - 3
DP  - 1987 Dec
TI  - Heart rate reflex responses during gestation in normotensive and spontaneously 
      hypertensive rats following angiotensin II and vasopressin.
PG  - 294-8
AB  - Gestation in the human and in rats is accompanied by a decrease in blood pressure 
      and a reduction of the pressor response to vasoconstrictor agents. In humans, the 
      decreased vascular reactivity to angiotensin II (AII) may occur simultaneously 
      with a state of increased baroreceptor sensitivity. We have consequently 
      evaluated the heart rate response to elevation of blood pressure following 
      administration of either AII or arginine8-vasopressin (AVP) in conscious 
      unrestrained, nonpregnant, or term-pregnant normotensive rats (Sprague-Dawley, 
      SDR; Wistar-Kyoto, WKR) and in spontaneously hypertensive rats (SHR). The 
      decrease in heart rate in response to increase in blood pressure by AII in 
      nonpregnant animals was similar in SDR and SHR, but much greater in WKR. The 
      heart rate response to increase in blood pressure by AVP was similar in all three 
      strains of cycling rats. Gestation (20th day) did not change the heart rate 
      response to increase in blood pressure by AII in normotensive animals, but 
      increased slightly the reflex responses in SHR, as shown by a significant 
      increase of the slope of the relationship of the decrement in heart rate versus 
      the increment of blood pressure. The heart rate response to increase in blood 
      pressure by AVP was greater during gestation in normotensive SDR and WKR, but not 
      in SHR. These results show that the heart rate responses to an increase in blood 
      pressure by vasoconstrictor peptides is dependent on the strain of animals used 
      and suggest that the baroreceptor reflexes play a minor role in the blunted 
      effect of vasconstrictor agens at the end of gestation in normotensive and 
      spontaneously hypertensive rats.
FAU - Massicotte, G
AU  - Massicotte G
AD  - Experimental Hypertension Laboratory, Clinical Research Institute of Montreal, 
      Quebec, Canada.
FAU - St-Louis, J
AU  - St-Louis J
FAU - Schiffrin, E L
AU  - Schiffrin EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Soc Exp Biol Med
JT  - Proceedings of the Society for Experimental Biology and Medicine. Society for 
      Experimental Biology and Medicine (New York, N.Y.)
JID - 7505892
RN  - 11000-17-2 (Vasopressins)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Pregnancy
MH  - Pregnancy, Animal/*drug effects
MH  - Rats
MH  - Rats, Inbred SHR/*physiology
MH  - Rats, Inbred Strains/*physiology
MH  - Rats, Inbred WKY/physiology
MH  - Vasopressins/*pharmacology
EDAT- 1987/12/01 00:00
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 1987/12/01 00:01 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 10.3181/00379727-186-42616 [doi]
PST - ppublish
SO  - Proc Soc Exp Biol Med. 1987 Dec;186(3):294-8. doi: 10.3181/00379727-186-42616.