PMID- 34232475
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20220321
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 45
IP  - 1
DP  - 2022 Jan
TI  - Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue 
      browning in mice.
PG  - 139-148
LID - 10.1007/s40618-021-01626-0 [doi]
AB  - PURPOSE: Caloric restriction (CR) and Roux-en-Y Gastric Bypass (RYGB) are 
      considered effective means of body weight control, but the mechanism by which CR 
      and RYGB protect against high-fat diet (HFD)-induced obesity remains elusive. The 
      browning of white adipose tissue (WAT) is a potential approach to combat obesity. 
      Here we assess whether browning of WAT is involved in CR- and RYGB-treatment. 
      METHODS: The average size of adipocytes was determined by histological analysis. 
      Expression of thermogenic genes in both human subjects and mice were measured by 
      quantitative real-time PCR and immunohistochemical staining. RESULTS: The average 
      size of adipocytes was bigger, while the expression of thermogenic genes such as 
      uncoupling protein 1 (UCP1), nuclear factor erythroid-2 like 1 (NRF1) and PPARgamma 
      coactivator-1 alpha (PGC1alpha) were lower in the WAT of obese subjects when compared to 
      lean controls. Both CR and RYGB promoted weight and fat loss. Increment of the 
      average adipocytes size and down-regulation of thermogenic genes were 
      significantly reversed by both CR and RYGB in the WAT of obese mice. CONCLUSIONS: 
      Our findings showed that CR and RYGB significantly improved high-fat diet-induced 
      lipid accumulation by promoting the browning of WAT.
CI  - (c) 2021. Italian Society of Endocrinology (SIE).
FAU - Huang, D
AU  - Huang D
AD  - Department of Physiology, School of Medicine, Jinan University, 601 Huangpu 
      Avenue West, Tianhe District, Guangzhou, 510632, Guangdong, China.
FAU - Zhang, Z
AU  - Zhang Z
AD  - Department of Physiology, School of Medicine, Jinan University, 601 Huangpu 
      Avenue West, Tianhe District, Guangzhou, 510632, Guangdong, China.
FAU - Dong, Z
AU  - Dong Z
AD  - Department of Obesity and Metabolic Surgery, The First Affiliated Hospital of 
      Jinan University, Guangzhou, China.
FAU - Liu, R
AU  - Liu R
AD  - Department of Physiology, School of Medicine, Jinan University, 601 Huangpu 
      Avenue West, Tianhe District, Guangzhou, 510632, Guangdong, China.
FAU - Huang, J
AU  - Huang J
AD  - Department of Physiology, School of Medicine, Jinan University, 601 Huangpu 
      Avenue West, Tianhe District, Guangzhou, 510632, Guangdong, China.
FAU - Xu, G
AU  - Xu G
AUID- ORCID: 0000-0002-5542-1350
AD  - Department of Physiology, School of Medicine, Jinan University, 601 Huangpu 
      Avenue West, Tianhe District, Guangzhou, 510632, Guangdong, China. 
      xugeyangliang@163.com.
LA  - eng
GR  - 81770794/National Natural Science Foundation of China/
GR  - 314010010/National Natural Science Foundation of China/
GR  - 21620423/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
DEP - 20210707
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
SB  - IM
MH  - Adipocytes, Brown/physiology
MH  - Adipocytes, White/physiology
MH  - Adipose Tissue, Brown/*physiology
MH  - Adipose Tissue, White/*physiology
MH  - Adult
MH  - Animals
MH  - *Caloric Restriction
MH  - Cell Transdifferentiation
MH  - Female
MH  - *Gastric Bypass
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - *Obesity/diet therapy/physiopathology/surgery
OTO - NOTNLM
OT  - Browning
OT  - Caloric restriction
OT  - Obesity
OT  - Roux-en-Y Gastric Bypass
EDAT- 2021/07/08 06:00
MHDA- 2022/03/22 06:00
CRDT- 2021/07/07 12:27
PHST- 2021/04/19 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/07/08 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
PHST- 2021/07/07 12:27 [entrez]
AID - 10.1007/s40618-021-01626-0 [pii]
AID - 10.1007/s40618-021-01626-0 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2022 Jan;45(1):139-148. doi: 10.1007/s40618-021-01626-0. 
      Epub 2021 Jul 7.