PMID- 34233864
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20230207
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 101
IP  - Pt B
DP  - 2021 Dec
TI  - MCP-1: Function, regulation, and involvement in disease.
PG  - 107598
LID - S1567-5769(21)00234-4 [pii]
LID - 10.1016/j.intimp.2021.107598 [doi]
AB  - MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) 
      ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the 
      process of inflammation, where it attracts or enhances the expression of other 
      inflammatory factors/cells. It leads to the advancement of many disorders by this 
      main mechanism of migration and infiltration of inflammatory cells like 
      monocytes/macrophages and other cytokines at the site of inflammation. MCP-1 has 
      been inculpated in the pathogenesis of numerous disease conditions either 
      directly or indirectly like novel corona virus, cancers, neuroinflammatory 
      diseases, rheumatoid arthritis, cardiovascular diseases. The elevated MCP-1 level 
      has been observed in COVID-19 patients and proven to be a biomarker associated 
      with the extremity of disease along with IP-10. This review will focus on 
      involvement and role of MCP-1 in various pathological conditions.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Singh, Sanjiv
AU  - Singh S
AD  - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical 
      Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, 
      Hajipur, Bihar, India. Electronic address: sanjivpg2006@yahoo.com.
FAU - Anshita, D
AU  - Anshita D
AD  - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical 
      Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, 
      Hajipur, Bihar, India.
FAU - Ravichandiran, V
AU  - Ravichandiran V
AD  - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical 
      Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, 
      Hajipur, Bihar, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210520
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Chemokine CCL2/genetics/*immunology/physiology
MH  - Chemotaxis
MH  - Disease
MH  - Humans
MH  - Monocytes/physiology
MH  - Oxidative Stress
PMC - PMC8135227
OTO - NOTNLM
OT  - CCL2
OT  - COVID-19
OT  - Cancer
OT  - Endothelial dysfunction
OT  - Monocyte chemoattractant protein-1
OT  - NF-kB
OT  - Oxidative stress
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/07/09 06:00
MHDA- 2021/12/21 06:00
PMCR- 2021/05/20
CRDT- 2021/07/08 05:47
PHST- 2021/01/22 00:00 [received]
PHST- 2021/02/25 00:00 [revised]
PHST- 2021/03/17 00:00 [accepted]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/07/08 05:47 [entrez]
PHST- 2021/05/20 00:00 [pmc-release]
AID - S1567-5769(21)00234-4 [pii]
AID - 107598 [pii]
AID - 10.1016/j.intimp.2021.107598 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2021 Dec;101(Pt B):107598. doi: 
      10.1016/j.intimp.2021.107598. Epub 2021 May 20.