PMID- 34234486
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Decreased Physiological Serum Total Bile Acid Concentrations in Patients with 
      Type 2 Diabetic Peripheral Neuropathy.
PG  - 2883-2892
LID - 10.2147/DMSO.S313488 [doi]
AB  - PURPOSE: Bile acids, amphipathic cholesterol metabolites, have been reported to 
      have cytoprotective and neuroprotective effects in humans and animal models. The 
      relationship of physiological serum total bile acid (TBA) levels with diabetic 
      peripheral neuropathy (DPN), however, has not been determined. The purpose of 
      this study was to investigate the relationship between physiological serum TBA 
      and DPN. PATIENTS AND METHODS: In total, 856 patients with type 2 diabetes 
      mellitus (T2DM) aged 20-89 years were enrolled in this cross-sectional study. 
      Serum TBA was measured, and its relationship with DPN and other parameters was 
      analyzed. RESULTS: T2DM patients with DPN had significantly lower serum TBA 
      compared with those without (P<0.01). Serum TBA was negatively associated with 
      glycated hemoglobin A1C, plateletcrit, fibrinogen, urine albumin-to-creatinine 
      ratio, vibration perception thresholds, and prevalence of DPN, peripheral 
      arterial disease, and diabetic foot ulceration after adjustment for age, sex, and 
      body mass index (P<0.01 or P<0.05). A graded association with prevalence of DPN 
      and increase in serum TBA quartiles was observed (P for trend <0.01), and there 
      was an 48.2% decreased risk of DPN in the highest quartile of serum TBA versus 
      the lowest quartile (95% CI 0.299-0.617; P=0.000) after multivariate adjustment. 
      Receiver-operating characteristic analysis revealed that the optimal cutoff point 
      of serum TBA to indicate DPN was 2.85 mumol/L (sensitivity 77.6% and specificity 
      45.6%). CONCLUSION: These findings suggest that lower physiological serum TBA 
      level may be associated with the prevalence of DPN in T2DM patients and may be a 
      potential biomarker for DPN.
CI  - (c) 2021 Yan et al.
FAU - Yan, Pijun
AU  - Yan P
AUID- ORCID: 0000-0001-6692-2401
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Zhang, Zhihong
AU  - Zhang Z
AD  - Department of General Medicine, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Tang, Qian
AU  - Tang Q
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Wu, Yuru
AU  - Wu Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Xu, Yong
AU  - Xu Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Miao, Ying
AU  - Miao Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan, 646000, People's Republic of China.
FAU - Zhao, Huan
AU  - Zhao H
AD  - Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of 
      China.
FAU - Liu, Ran
AU  - Liu R
AD  - Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210628
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8254093
OTO - NOTNLM
OT  - Chinese population
OT  - diabetic peripheral neuropathy
OT  - total bile acid
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/07/09 06:00
MHDA- 2021/07/09 06:01
PMCR- 2021/06/28
CRDT- 2021/07/08 06:37
PHST- 2021/03/31 00:00 [received]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/07/08 06:37 [entrez]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/07/09 06:01 [medline]
PHST- 2021/06/28 00:00 [pmc-release]
AID - 313488 [pii]
AID - 10.2147/DMSO.S313488 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Jun 28;14:2883-2892. doi: 10.2147/DMSO.S313488. 
      eCollection 2021.