PMID- 34234495
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210709
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus 
      Treatment.
PG  - 2985-2999
LID - 10.2147/DMSO.S310166 [doi]
AB  - Autophagy has been reported to involve in the pathogenesis of type 2 diabetes 
      mellitus (T2DM), which protects the insulin target tissues and pancreatic 
      beta-cells. However, autophagy is inhibited when the cells are lipid overload. That, 
      in turn, increases the accumulation of fat. Lipotoxicity caused by excessive 
      lipid accumulation contributes to pathogenesis of T2DM. Therefore, it is 
      undeniable to break the vicious circles between lipid excess and autophagy 
      deficiency. Lipophagy, a selective form of autophagy, is characterized by 
      selective breakdown of lipid droplets (LDs). The nutritional status of cells 
      contributes to the way of autophagy (selective or non-selective), while selective 
      autophagy helps to accurately remove excess substances. It seems that lipophagy 
      could be an effective means to decrease abnormal lipid accumulation that leads to 
      insulin resistance and beta-cell impairment by removing ectopic LDs. Based on this 
      process, many natural compounds have been reported to decrease lipid accumulation 
      in tissues through autophagy-lysosomal pathway, which gradually highlights the 
      significance of lipophagy. In this review, we focus on the mechanisms that 
      lipophagy improves T2DM and natural products that are applied to induce 
      lipophagy. It is also suggested that natural herbs with rich contents of natural 
      products inducing lipophagy would be potential candidates for alleviating T2DM.
CI  - (c) 2021 Huang et al.
FAU - Huang, Mingyue
AU  - Huang M
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      611130, People's Republic of China.
AD  - Beijing Key Laboratory of Bio-Characteristic Profiling for Evaluation of Rational 
      Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, 
      People's Republic of China.
FAU - Yang, Xinyu
AU  - Yang X
AD  - Beijing Key Laboratory of Bio-Characteristic Profiling for Evaluation of Rational 
      Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, 
      People's Republic of China.
FAU - Wang, Zhenzhen
AU  - Wang Z
AD  - Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, People's Republic of China.
FAU - Long, Jianglan
AU  - Long J
AD  - Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, People's Republic of China.
FAU - Wang, Aiting
AU  - Wang A
AD  - Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, People's Republic of China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Traditional Chinese Medicine and Natural Medicine, Chongqing 
      Institute for Food and Drug Control, Chongqing, 401121, People's Republic of 
      China.
FAU - Yan, Dan
AU  - Yan D
AD  - Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, 
      Beijing, 100050, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210630
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8256822
OTO - NOTNLM
OT  - autophagy
OT  - lipid metabolism
OT  - lipophagy
OT  - natural products
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/07/09 06:00
MHDA- 2021/07/09 06:01
PMCR- 2021/06/30
CRDT- 2021/07/08 06:37
PHST- 2021/03/09 00:00 [received]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/07/08 06:37 [entrez]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/07/09 06:01 [medline]
PHST- 2021/06/30 00:00 [pmc-release]
AID - 310166 [pii]
AID - 10.2147/DMSO.S310166 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Jun 30;14:2985-2999. doi: 10.2147/DMSO.S310166. 
      eCollection 2021.