PMID- 34234538
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 14
DP  - 2021
TI  - Correlation Between 25 Hydroxyvitamin D Levels and Nonalcoholic Fatty Liver 
      Disease in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional 
      Study.
PG  - 3099-3107
LID - 10.2147/IJGM.S319449 [doi]
AB  - PURPOSE: We aimed to analyze the serum vitamin D level in Chinese patients with 
      type 2 diabetes mellitus (T2DM) and discuss its correlation with nonalcoholic 
      fatty liver disease (NAFLD). PATIENTS AND METHODS: A total of 300 patients with 
      T2DM (92 patients without NAFLD and 208 patients with NAFLD) were enrolled, and 
      25-hydroxyvitamin D [25-(OH)D] levels were compared between the two groups. 
      Second, the NAFLD fibrosis score (NFS) and fatty liver index (FLI) were used to 
      group patients with T2DM complicated by NAFLD, and the differences in serum 
      25-(OH)D in patients with different degrees of liver fibrosis were compared. 
      Third, multiple regression analysis was used to analyze the independent 
      predictors of liver fibrosis in patients with T2DM complicated by NAFLD. RESULTS: 
      The level of 25-(OH)D in patients with T2DM complicated by NAFLD was 
      significantly lower than that in patients with T2DM alone. Based on the NFS and 
      FLI, the 25-(OH)D level of the hepatic fibrosis subgroup was significantly lower 
      than that of the subgroup without liver fibrosis. 25-(OH)D was found to be an 
      independent predictor of liver fibrosis in patients with T2DM complicated by 
      NAFLD. CONCLUSION: The serum 25-(OH)D level in patients with T2DM complicated by 
      NAFLD was significantly reduced, and the 25-(OH)D level showed a gradual downward 
      trend with the degree of liver fibrosis. Low concentrations of 25-(OH)D may be 
      indicative of the degree of liver fibrosis in diabetic patients.
CI  - (c) 2021 Xiu et al.
FAU - Xiu, Lei
AU  - Xiu L
AD  - Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, 100038, People's Republic of China.
FAU - Jiang, Tao
AU  - Jiang T
AUID- ORCID: 0000-0003-2081-1997
AD  - Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, 100038, People's Republic of China.
FAU - Yao, Xiao-Ai
AU  - Yao XA
AD  - Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, 100038, People's Republic of China.
FAU - Wen, Zhen
AU  - Wen Z
AD  - Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, 100038, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC8257066
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - liver fibrosis
OT  - nonalcoholic fatty liver disease
OT  - type 2 diabetes mellitus
COIS- All authors have no conflicts of interest to declare.
EDAT- 2021/07/09 06:00
MHDA- 2021/07/09 06:01
PMCR- 2021/07/01
CRDT- 2021/07/08 06:37
PHST- 2021/05/16 00:00 [received]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2021/07/08 06:37 [entrez]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/07/09 06:01 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 319449 [pii]
AID - 10.2147/IJGM.S319449 [doi]
PST - epublish
SO  - Int J Gen Med. 2021 Jul 1;14:3099-3107. doi: 10.2147/IJGM.S319449. eCollection 
      2021.