PMID- 34234914
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210709
IS  - 2000-9666 (Print)
IS  - 2000-9666 (Electronic)
IS  - 2000-9666 (Linking)
VI  - 11
IP  - 3
DP  - 2021
TI  - Fallopian tube cancer- challenging to diagnose but not as infrequent as 
      originally thought.
PG  - 393-396
LID - 10.1080/20009666.2021.1893889 [doi]
AB  - Background: Primary fallopian tube carcinoma (PFTC) is a rare gynecological 
      malignancy though its prevalence may be underestimated given that most 'ovarian' 
      serous cancers originate in the fallopian tube. Its diagnosis is challenging due 
      to its vague signs and symptoms on presentation and it is frequently 
      under-diagnosed pre-operatively. Case Presentation: We present a case of a 
      pre-menopausal woman who presented with vaginal bleeding. Her laboratory testing 
      and physical examination were grossly unremarkable. Gynecologic ultrasound 
      demonstrated multiple uterine fibroids and a double layer endometrium measuring 
      4.5 mm. More importantly, the left ovary was seen with a complex cyst with mildly 
      echogenic fluid and a solid excerscence. These findings were suspicious for 
      malignancy. The clinical and radiological findings with elevated CA-125 were 
      consistent with a malignant process. Patient subsequently underwent a diagnostic 
      laparoscopy, which required conversion to exploratory laparotomy, supracervical 
      hysterectomy, bilateral salpingo-oophorectomy, right ureteral lysis, right 
      para-aortic and right pelvic lymph node debulking and omentectomy. Biopsy of left 
      fallopian tube and ovary revealed invasive high-grade serous carcinoma of 
      fallopian tube, with involvement of lymphovascular spaces and with surface 
      involvement. Peritoneal washings were negative for malignancy. She was diagnosed 
      with a high-grade serous carcinoma of the fallopian tube after undergoing an 
      endometrial biopsy, multiple imaging tests and finally surgical intervention that 
      yielded the diagnosis. She was started on chemotherapy with carboplatin and 
      paclitaxel. Conclusion: Our aim is to highlight the importance of having PFTC 
      among the differential diagnosis when women present with vaginal bleeding or 
      abdominal pain, as the clinical presentation of PFTC tends to be non-specific, 
      and is often under-diagnosed; reviewing the diagnosis and management, and 
      characterizing the similarities and differences of PFTC with other gynecological 
      malignancies such as ovarian cancer.
CI  - (c) 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group on behalf of Greater Baltimore Medical Center.
FAU - Hundal, Jasmin
AU  - Hundal J
AD  - Department of Medicine, University of Connecticut Health Center, Trinity Health 
      of New England - Saint Francis Hospital, Hartford, USA.
FAU - Lopetegui-Lia, Nerea
AU  - Lopetegui-Lia N
AUID- ORCID: 0000-0002-6207-2371
AD  - Department of Medicine, University of Connecticut Health Center, Trinity Health 
      of New England - Saint Francis Hospital, Hartford, USA.
FAU - Rabitaille, William
AU  - Rabitaille W
AD  - Department of Medicine, University of Connecticut Health Center, Trinity Health 
      of New England - Saint Francis Hospital, Hartford, USA.
LA  - eng
PT  - Case Reports
DEP - 20210510
PL  - United States
TA  - J Community Hosp Intern Med Perspect
JT  - Journal of community hospital internal medicine perspectives
JID - 101601396
PMC - PMC8118448
OTO - NOTNLM
OT  - Primary fallopian tube carcinoma
OT  - internal medicine
OT  - pre-menopausal female
OT  - women's health
COIS- No potential conflict of interest was reported by the authors.
EDAT- 2021/07/09 06:00
MHDA- 2021/07/09 06:01
PMCR- 2021/05/10
CRDT- 2021/07/08 06:41
PHST- 2021/07/08 06:41 [entrez]
PHST- 2021/07/09 06:00 [pubmed]
PHST- 2021/07/09 06:01 [medline]
PHST- 2021/05/10 00:00 [pmc-release]
AID - 1893889 [pii]
AID - 10.1080/20009666.2021.1893889 [doi]
PST - epublish
SO  - J Community Hosp Intern Med Perspect. 2021 May 10;11(3):393-396. doi: 
      10.1080/20009666.2021.1893889. eCollection 2021.